2015
DOI: 10.1534/genetics.114.173617
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Novel Tools for Genetic Manipulation of Follicle Stem Cells in the Drosophila Ovary Reveal an Integrin-Dependent Transition from Quiescence to Proliferation

Abstract: In many tissues, the presence of stem cells is inferred by the capacity of the tissue to maintain homeostasis and undergo repair after injury. Isolation of self-renewing cells with the ability to generate the full array of cells within a given tissue strongly supports this idea, but the identification and genetic manipulation of individual stem cells within their niche remain a challenge. Here we present novel methods for marking and genetically altering epithelial follicle stem cells (FSCs) within the Drosoph… Show more

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Cited by 24 publications
(96 citation statements)
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“…The GAL4/UAS system has played an important role in research using many model organisms. Hartman et al (2015) utilized an extensive collection of fly lines from multiple sources with GAL4 is expressed in a specific cell type based on the enhancer/promoter element located near the GAL4 insertion site in the genome. Flies containing this insertion are mated to another fly line that contains a target gene downstream of the UAS element.…”
Section: Regulation Of Gene Expressionmentioning
confidence: 99%
See 4 more Smart Citations
“…The GAL4/UAS system has played an important role in research using many model organisms. Hartman et al (2015) utilized an extensive collection of fly lines from multiple sources with GAL4 is expressed in a specific cell type based on the enhancer/promoter element located near the GAL4 insertion site in the genome. Flies containing this insertion are mated to another fly line that contains a target gene downstream of the UAS element.…”
Section: Regulation Of Gene Expressionmentioning
confidence: 99%
“…As one of the authors' goals was to examine the shape, or morphology, of cells, it was disadvantageous to have adjacent cells labeled as they become difficult to distinguish. Therefore, Hartman et al (2015) further refined the MARCM technique to control when labeled daughter cells are generated. Following the induction of clones by heat shock, they allowed the labeled daughter cells to differentiate into follicle cells and exit the germarium.…”
Section: Hartmanmentioning
confidence: 99%
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