Novel thermosensitive hydrogels based on methoxy polyethylene glycol-co-poly(lactic acid-co-aromatic anhydride) for cefazolin delivery

Lai, Po‐Liang; Hong, Ding-Wei; Ku, Kuan-Lin; Lai, Zhi-Teng; Chu, I‐Ming

doi:10.1016/j.nano.2013.09.005

Cited by 24 publications

(19 citation statements)

References 26 publications

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“…Based on integration of the peak areas, the number of repeating units (n) of LLA and the molecular weight of the diols could be calculated ( Table 2). 45 The molecular weights and polydispersity (PDI) of the synthesized polymers were also determined using GPC (Table 2), with the molecular weights of the PEG successfully increased by adjusting the molar ratio of LLA to PEG4000 from 2 : 1 to 5 : 1. The results indicate that the M n (NMR) values of the synthesized polymers were close to the theoretical molecular weight, while GPC analysis gave PDIs of about 1.1.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable pH-responsive hydrogels for controlled dual-drug release

Qiu

Yang

et al. 2018

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

“…S8 in the ESI †), in agreement with the results of the other hydrogels. 45,46 Antibacterial experiments showed that the dual-drug loaded hydrogels formed inhibition zones on agar surfaces coated with E. coli after 24 h of incubation (see the Methods section, Fig. S10 in the ESI †).…”

Section: Drug Release From the Hydrogelsmentioning

confidence: 99%

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Qiu

Yang

et al. 2018

J. Mater. Chem. B

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“…Cephalosporin is a widely used neutrapen‐resistant and broad‐spectrum β‐lactamase‐based antibiotic . Hydrogels containing cefditoren pivoxil achieved gastroretentive effect and methoxy poly(ethylene glycol)‐ co ‐poly(lactic acid‐ co ‐aromatic anhydride) hydrogels containing cefazolin offered a stable release profile without an initial burst release and effective antibacterial properties against E. coli . Levofloxacin‐loaded hyaluronic acid hydrogels were reported to be able to attack bacteria within the cells for both S. aureus and P. aeruginosa strains .…”

Section: Antibiotic‐loaded Hydrogelsmentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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“…192 Cefditoren pivoxil hydrogels with gastroretentive effect were achieved, 193 and cefazolin containing methoxy PEG-co-poly(lactic acidco-aromatic anhydride) hydrogels offered a stable release without initial burst. 194 Levofloxacin-loaded hyaluronic acid hydrogels were reported to be able to chase bacteria within the cells for both S. aureus and P. aeruginosa strains. 127 In order to eradicate bacterial biofilm and avoid possible intestinal obstructions, Islan et al 195 reported a smart autodegradable hydrogel containing alginate lyase (AL) and levofloxacin, which induced the reduction of drug toxicity and enhancement of drug bioavailability.…”

Section: Other Antibioticsmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

302

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Novel thermosensitive hydrogels based on methoxy polyethylene glycol-co-poly(lactic acid-co-aromatic anhydride) for cefazolin delivery

Cited by 24 publications

References 26 publications

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Antibacterial Hydrogels

Antimicrobial hydrogels: promising materials for medical application

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