Novel Therapy for Oral Cancer - Gene Therapy an Update

Kumar, Naina; Agrawal, Anchala; Sreedevi, R.

doi:10.9734/bjmmr/2015/15317

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…4,6 The genetic material can be either directly introduced into the body (in vivo) or the gene is delivered into the target cell and re-introduced into the body (ex vivo) 4,7 Genes can be transferred into cells through either physical techniques (electroporation, microinjection, ballistic material) or chemical techniques (calcium phosphate, liposome, and protein complexes). 8,9 Genetic Approach toward SCCHN Strategies for gene therapy: There are several general strategies utilized in a gene therapy approach to cancer, including:…”

Section: Gene Transfermentioning

confidence: 99%

Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Marimuthu,

Subramani,

Deepika

et al. 2024

Dental Journal of Advance Studies

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Background:The evolution of gene therapy, conceptualized in the 1960s, reached a pivotal moment in [1989][1990] with the approval of the first human clinical studies. Gene therapy, as defined by the US Food and Drug Administration (FDA), involves the administration of genetic material via nucleic acids, viruses, or genetically engineered microorganisms. This review explores the historical development and current landscape of gene therapy, focusing on its applications in dentistry. Materials and methods:A comprehensive narrative literature search, utilizing PubMed, MEDLINE, Scopus, and Web of Science databases, was conducted. Keywords and MeSH terms related to gene therapy, CRISPR/Cas technology, and dentistry were employed. Inclusion criteria encompassed English-language publications from the last 10 years, specifically focusing on the gene therapy or CRISPR/Cas applications in dentistry. Data synthesis involved critical appraisal and extraction of relevant information. Results: Gene transfer, a cornerstone of gene therapy, involves modifying defective genes through the injection of genetically modified vectors into target cells, either in vivo or ex vivo. Various methods, including physical (electroporation, microinjection) and chemical (calcium phosphate, liposome) approaches, facilitate gene modification. Dentistry applications range from addressing diseases such as squamous cell carcinoma and Sjogren's syndrome to enhancing bone regeneration, implants, and managing chronic pain. Conclusion:The potential of gene therapy and CRISPR/Cas technology in dentistry is vast, offering innovative, personalized therapeutic interventions. However, challenges such as ethical considerations and the need for long-term efficacy studies must be addressed to ensure the transformative impact of these technologies on oral healthcare practices. The future promises a paradigm shift in dental care, with gene therapy leading the way towards more effective and targeted treatments.

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Section: Gene Transfermentioning

confidence: 99%

Gene Therapy and CRISPR/Cas Technology in Dentistry: A Review

Marimuthu,

Subramani,

Deepika

et al. 2024

Dental Journal of Advance Studies

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“…Also, a treated case with this vaccine revealed an increase in the immune response at 10 months of inoculation of tongue metastasis of OSCC. [ 32 ]…”

Section: Techniques Employed In Gene Therapymentioning

confidence: 99%

Gene therapy as a treatment of oral cancer: An insight

Modak,

Solomon,

Karmakar

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Oral cancer or oral squamous cell carcinoma comprises more than three-fourth of all the malignant neoplasms of the oral cavity. Worldwide, it is the 18th most common malignancy. The patients suffering from cancer usually remains immune to the standard therapies such as surgical resection of tumours, radiotherapy and chemotherapy; however, there can be probabilities of chronic and acute toxicities and secondary malignancies as well. Recently, gene therapy has been introduced in the arena of biomedicine to improve the treatment modality for oral malignant and potentially malignant disorders. It replaces the defective gene followed by repairing by a therapeutic gene. Gene therapy can attack cancerous cells without causing harmful effect to the normal tissue. It is useful to cope with the relapse of diseases and as a synergetic treatment. The present article reviewed the types of gene therapy, modes of delivery of the therapeutic genes and different techniques used along with pros and cons of gene therapy.

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