Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose

Jin, Shiying; Du, Zhongyao; Guo, Huiyuan; Zhang, Hao; Ren, Fazheng; Wang, Pengjie

doi:10.3390/ijms20030697

Cited by 17 publications

(7 citation statements)

References 40 publications

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“…The clathrin/caveolin independent pathway also contributes to cell entry of metal oxide NPs. The, clathrin/caveolin independent pathway is important in the uptake of cellular fluids, hormones, and folic acid, and folic acid is of particular interest given its role in targeting nanomaterials to certain forms of solid tumors [ 112 , 113 ]. Macropinocytosis and micropinocytosis play minor roles in the cellular trafficking of metal oxides in most studies, and consequently they will not be considered further in this review.…”

Section: Mechanisms Of Cellular Uptake and Trafficking Of Nanoparticlesmentioning

confidence: 99%

Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems

Erlichman

Leiter

2021

Antioxidants

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Metal oxide nanoparticles (NPs) have received a great deal of attention as potential theranostic agents. Despite extensive work on a wide variety of metal oxide NPs, few chemically active metal oxide NPs have received Food and Drug Administration (FDA) clearance. The clinical translation of metal oxide NP activity, which often looks so promising in preclinical studies, has not progressed as rapidly as one might expect. The lack of FDA approval for metal oxide NPs appears to be a consequence of the complex transformation of NP chemistry as any given NP passes through multiple extra- and intracellular environments and interacts with a variety of proteins and transport processes that may degrade or transform the chemical properties of the metal oxide NP. Moreover, the translational models frequently used to study these materials do not represent the final therapeutic environment well, and studies in reduced preparations have, all too frequently, predicted fundamentally different physico-chemical properties from the biological activity observed in intact organisms. Understanding the evolving pharmacology of metal oxide NPs as they interact with biological systems is critical to establish translational test systems that effectively predict future theranostic activity.

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Section: Mechanisms Of Cellular Uptake and Trafficking Of Nanoparticlesmentioning

confidence: 99%

Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems

Erlichman

Leiter

2021

Antioxidants

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“…By designing the ligands of the characteristic molecules of tumor cells on the surface of the nanoparticles, the specific binding between the nanoparticles and the tumor cells is promoted. In order to achieve targeted therapy of tumors, increase the concentration of drugs in the target area, thereby improving the utilization and efficacy of drugs and reducing adverse drug reactions [12,13]. Studies have shown that the PAH model pulmonary arteriole media smooth muscle cell surface glucose transporter-1 (GLUT-1) is highly expressed, aerobic glycolysis is enhanced, and 18 fluorodeoxyglucose (18F-FDG) uptake is increased [14].…”

Section: Introductionmentioning

confidence: 99%

The Levels of TNF-α, Tissue Factor, and Coagulation Function in Rats with Pulmonary Hypertension and the Intervention Effect of Sildenafil Encapsulated by Targeted Nanocarriers

Xuan¹,

Wang²,

Xie³

et al. 2022

Computational and Mathematical Methods in Medicine

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Pulmonary hypertension (PAH) is a proliferative disease of pulmonary blood vessels, but the pathogenesis of pulmonary hypertension is still unclear. This article explores the role of tumor necrosis factor-α (TNF-α), tissue factor (TF), and coagulation function (CF) in the pathogenesis of PAH. PAH is often accompanied by vascular intima injury and muscular arterial media thickening. Coupled with the wide application of nanotargeted drugs in recent years, a targeted nanocarrier encapsulating sildenafil was prepared in this study. The particle size, PDI, zeta potential, drug loading, and encapsulation efficiency were 194.32 ± 17.31 nm , 0.28 ± 0.02 , − 6.34 ± 0.33 , 24.61%, and 70.52%. The monocrotaline PAH rat model was constructed, and it was found that the levels of TNF-α, TF, and CF in the peripheral blood of PAH rats were abnormally increased. 30 PAH rats were randomly divided into 5 groups and injected with saline (NS group), sildenafil (sildenafil group), target the nanoempty carrier (TNC-E group), ordinary nanocarrier encapsulated sildenafil (CNC-sildenafil group), and targeted nanocarrier encapsulate sildenafil (TNC-sildenafil group). Compared with the NS group, the mean pulmonary artery pressure in the TNC-sildenafil group was lower ( P < 0.05 ). Compared with the normal rat group, the pulmonary small blood vessel media thickness, TNF-α level, TF level, and the area of myocardial cells were increased in the NS group, sildenafil group, TNC-E group, and CNC-sildenafil group ( P < 0.05 ). Compared with the NS group, the pulmonary small blood vessel media thickness, myocardial cell area, and the levels of TNF-α and TF in the TNC-sildenafil group were reduced ( P < 0.05 ). Targeting nanocarrier encapsulation of sildenafil can obviously reduce the average pulmonary artery pressure in rats with pulmonary hypertension, improve pulmonary vascular media proliferation and myocardial hypertrophy, and restore the levels of TNF-α, TF, and CF to a normal state.

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“…The preparation of FA-2-DG has been reported previously [39]. The structure of FA-2-DG was confirmed with FTIR, nuclear magnetic resonance, and MS. All solvents and biochemical reagents were of analytical grade and were purchased from commercial sources (J&K Scientific, Beijing, China; Solarbio Science & Technology, Beijing, China).…”

Section: Methodsmentioning

confidence: 79%

2-Deoxyglucose-Modified Folate Derivative: Self-Assembling Nanoparticle Able to Load Cisplatin

Jin

Wang

et al. 2019

Molecules

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Folic acid has been widely introduced into nano-drug delivery systems to give nanoparticle-targeted characteristics. However, the poor water solubility of folic acid may hinder the exploitation of its ability to load antineoplastic drugs. In the present study, we designed a new folate derivative (FA-2-DG) synthesized from folic acid and 2-Deoxyglucose (2-DG). The aim of this study was to evaluate the self-assembly characteristics of FA-2-DG, and its ability of loading cisplatin. The critical micelle concentration was 7.94 × 10−6 mol L−1. Fourier transform infrared spectroscopy indicated that hydrogen bonding interaction is a main driving force for the self–assembly of FA-2-DG. The particle was stable in pure water or 0.5% bovine serum albumin dispersions. By forming a coordination bond, the particles assembled from FA-2-DG can load cisplatin. The loading efficiency was maximal when the molar ratio of FA-2-DG to cisplatin was 2:1.

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Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose

Cited by 17 publications

References 40 publications

Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems

Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems

The Levels of TNF-α, Tissue Factor, and Coagulation Function in Rats with Pulmonary Hypertension and the Intervention Effect of Sildenafil Encapsulated by Targeted Nanocarriers

2-Deoxyglucose-Modified Folate Derivative: Self-Assembling Nanoparticle Able to Load Cisplatin

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