Novel synthetic organic compounds inspired from antifeedant marine alkaloids as potent bacterial biofilm inhibitors

Rane, Rajesh A.; Karpoormath, Rajshekhar; Naphade, Shital S.; Bangalore, Pavan Kumar; Shaikh, Mahamadhanif S.; Hampannavar, Girish A.

doi:10.1016/j.bioorg.2015.06.001

Cited by 10 publications

(2 citation statements)

References 18 publications

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“…In particular, marine sponges are a rich source of antibacterial compounds with different mode of action. Dihydrosventrin and sventrin, bromopyrrole alkaloids, isolated from marine sponges, are biofilm inhibitors at 51 and 74 µM against P. aeruginosa [10]. The 2-aminoimidazole oroidin, a marine alkaloid, isolated from the marine sponge Agelas conifer , and its analogues are studied for antibiofilm activity [11].…”

Section: Introductionmentioning

confidence: 99%

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

et al. 2018

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New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.

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Section: Introductionmentioning

confidence: 99%

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

et al. 2018

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“…Some compounds showed notable antibiofilm activity and no bactericidal effect, which can effectively control biofilm formation without affecting the growth of planktonic bacteria, reducing the possibility of bacterial resistance formation (Deng et al., 2022). In addition, synthetic compounds inspired by marine alkaloids have proven to be potent inhibitors of bacterial biofilm (Khadake et al., 2021; Rane et al., 2015). For example, structural modifications of bromotyrosine alkaloids were found to improve their antimicrobial activity (Andjouh & Blache, 2015, 2019).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vitro evaluation of antibacterial and antibiofilm activities of novel triphenylphosphonium‐functionalized substituted pyrimidines

Muzychka,

Humeniuk,

Boiko

et al. 2024

Chem Biol Drug Des

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The increase in the prevalence of antibiotic‐resistant pathogens leads to a decrease in the number of antimicrobial agents for the treatment of infections and prompts researchers to search for new effective antimicrobial drugs. This study reports the synthesis of novel triphenylphosphonium‐functionalized substituted pyrimidines and in vitro evaluation of their antibacterial and antibiofilm activity. Most of the synthesized derivatives showed high antibacterial activity (MIC = 0.39–1.56 μg/mL) against the methicillin‐resistant strain of S. aureus 222. Compounds 2a and 11 exhibited a high level of antibiofilm activity against S. aureus 222 and E. coli 311. The triphenylphosphonium‐containing pyrimidines 11 and 2a reduced S. aureus 222 biofilm formation by 99.1% and 95.8%, respectively. In addition, compound 2a was the most active against E. coli 311 biofilm formation (the biomass decreased by 98.4%).

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