Antibacterial and antibiofilm activities of synthetic analogs of 3-alkylpyridine marine alkaloids

Antibacterial, anti-biofilm, and anti-adhesive activities of melittin, a honeybee venom-derived peptide, against quinolone-resistant uropathogenic Escherichia coli (UPEC)

“…Mature biofilm: The effects of melittin on the disruption of the established biofilm of a quinolone-resistant and ESBL-producing UPEC strain (EC49) was evaluated using the microtiter plate biofilm formation assay as previously described (Herrera et al 2020). The UPEC inoculum at 1x10 6 CFU/mL was incubated at 35±2 o C for 24 h in tryptic Soy Broth (TSB) supplemented with 1 mM glucose to allow biofilm formation and adhesion.…”

Antifungal activity of a novel 3-Alkylpyridine analog derived from Marine sponge alkaloids

“…Thus, this study aimed to evaluate the anti-Candida spectrum of seven synthetic 3-alkylpyridine alkaloid (3-APA) analogs, which presented antibacterial and antibiofilm activities against relevant bacterial pathogens, such as Klebsiella pneumoniae and Staphylococcus aureus in a previous study (Herrera et al 2020). Moreover, for the most promising alkaloid, we determined its effect on the fungal membrane ergosterol and cell wall, the anti-virulence activity (i.e., potential to inhibit the yeastto-hypha transition), and the toxicity against mammalian cells using renal lineages (Vero and BHK-21).…”