Novel Synthesis of Anthelmintic Drug 4-Isothiocyanato-4′-nitrodiphenyl Ether and Its Analogs

Triton-B Catalyzed One Pot Multicomponent Synthesis of Isothiocyanates in Non-Aqueous Medium

“…The most conventional method remains the treatment with thiophosgene [33]. Isothiocyanates have been also reported to be prepared by monoarylisothioureas [34], phosphoramidates [35], iminodithiazoles [36], tertiary alcohols [37][38][39], amines [40][41][42][43][44][45][46], nitrile oxides [47][48][49], isocyanides [50][51][52], isocyanates [53], by decomposition of dithiocarbamates [54], dithiocarbamic acid [55], peptide coupling reagents [56], di-tertbutyldicarbonate [57], bis-(trichloromethyl)carbonate (BTC) [58], etc. However, most of these methods offer low yields, inconvenient workup procedures, poor stability, expensive…”