Novel Sutureless Transplantation of Bioadhesive-Coated, Freeze-Dried Amniotic Membrane for Ocular Surface Reconstruction

Sekiyama, Eiichi; Nakamura, Takahiro; Kurihara, Eiji; Cooper, Leanne J.; Fullwood, Nigel J.; Takaoka, Maho; Hamuro, Junji; Kinoshita, Shigeru

doi:10.1167/iovs.06-1104

Cited by 36 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sekiyama et al performed sutureless AMT with fibrin glue for ocular reconstruction of rabbit eyes [91]. They prepared a freezedried (FD) AM that was coated with fibrin glue (Tisseel).…”

Section: Amtmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

View full text Add to dashboard Cite

“…Sekiyama et al performed sutureless AMT with fibrin glue for ocular reconstruction of rabbit eyes [91]. They prepared a freezedried (FD) AM that was coated with fibrin glue (Tisseel).…”

Section: Amtmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

View full text Add to dashboard Cite

“…[4][5][6][7][8] In addition, the outcomes of AMT using fibrin glue for corneal ulceration, perforation, and ocular surface reconstruction have been reported in clinical and experimental studies. [9][10][11][12][13] However, the results of pterygium surgery with AMT using fibrin tissue sealants have been evaluated in limited number of studies. Pfister and Sommers 14 were the first to report the use of fibrin glue for amniotic membrane grafting in two patients with primary and in one with recurrent pterygium.…”

Section: Introductionmentioning

confidence: 99%

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

View full text Add to dashboard Cite

Purpose To compare the results of amniotic membrane transplantation (AMT) using fibrin glue vs vicryl sutures in pterygium surgery. Methods We carried out a prospective, randomised clinical study of 70 eyes (70 patients) with primary pterygium. After the removal of pterygium, patients were randomised to undergo AMT using fibrin glue (Tisseel, 32 eyes) or 8-0 vicryl sutures (38 eyes). Clinical examination and digital photographing were performed at each visit and the patients were followed up for at least 12 months. Post-operative symptoms in the first month were evaluated according to a fivepoint scale. Final appearances were graded from 1 to 4 in which grade 4 represented true (corneal) recurrence and grade 3 indicated conjunctival recurrence. Results The average operation time in the fibrin glue and suture groups were 11.2 ± 2.4 min (mean ± SD) and 18.7 ± 2.2 min, respectively (P ¼ 0.018). Significantly fewer post-operative symptoms were observed in the fibrin glue group at post-operative days 1, 7, and 14 (Po0.05 for all). At the end of the follow-up, true recurrence (grade 4) was developed in three eyes (9.4%) in the fibrin glue group, and in four eyes (10.5%) in the suture group (P ¼ 0.33). The rates of conjunctival recurrence (grade 3) were 21.9% (seven eyes) and 23.7% (nine eyes) in the fibrin glue and suture groups, respectively (P ¼ 0.38). Conclusions Amniotic membrane grafts can be successfully attached without any major complication in patients undergoing pterygium surgery. In addition, it is effective in shortening the duration of surgery and preventing post-operative discomfort. Although there seems to be no difference in the recurrence rates and cosmetic outcomes between both groups, neither technique represents best results.

show abstract

“…These findings were essentially corroborated in another study (Sekiyama et al, 2007). The fibrin bioadhesive biodegrades within 2 weeks, whereas the amniotic membrane persists for at least 12 weeks, providing sufficient time for epithelialization (Sekiyama et al, 2007). Sutureless transplantation with fibrin glue or ProKera™ is reportedly a safe and easy method that avoids complications related to sutures and shortens the time of surgery (Kheirkhah et al, 2006).…”

Section: Human Amniotic Membrane Transplantationmentioning

confidence: 62%

“…The authors found that suture fixation tends to promote membrane contraction, raised membrane edges, and epithelial ingrowth into the submembrane space (Szurman et al, 2006). These findings were essentially corroborated in another study (Sekiyama et al, 2007). The fibrin bioadhesive biodegrades within 2 weeks, whereas the amniotic membrane persists for at least 12 weeks, providing sufficient time for epithelialization (Sekiyama et al, 2007).…”

Section: Human Amniotic Membrane Transplantationmentioning

confidence: 72%