Novel strategies for designing regenerative skin products for accelerated wound healing

Katiyar, Soumya; Singh, Divakar; Shikha, Kumari; Srivastava, Pradeep; Mishra, Abha

doi:10.1007/s13205-022-03331-y

Cited by 7 publications

(1 citation statement)

References 210 publications

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“…[59] On account of the dissimilar actions produced by immune responses on the progression of different disorders, the therapeutic benefits of hydrogels could be ascribed to promotive roles or inhibitory functions on the immune system. [60] As it is known that persistent infection and failure of neovascularization, provoked by dysregulated immunological reactions, are deeply implicated in the pathogenesis of DFUs, one pivotal mechanism by which hydrogels exert pro-healing activities is associated with improving the imbalance of immune homeostasis. [61] Hybrid hydrogels consisting of cationic chitosan/anionic dextran and elastin-based hydrogels recruit macrophages and neutrophils in the wound site, which is profitable for eliminating invading pathogens and necrotic tissues (Figure 5A,B).…”

Section: Hydrogels Alonementioning

confidence: 99%

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Xiong

Qian

Lü

et al. 2023

Adv Funct Materials

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Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing physical and mental challenges for patients due to the lack of efficient curative therapy. Despite considerable advances in pharmacological and surgical approaches, clinical trials for DFU patients remain disappointing due to the local overactive and excessive inflammation. Immunomodulatory hydrogels has significant advantages to overcome the clinical challenge of DFUs therapy. Here, recent fabrication and regenerative advances in the utilization of functional hydrogels for altering the immune microenvironment of DFUs are comprehensively reviewed. The pathological features and the healing processes of DFUs, followed by summarizing the physicochemical properties essential for the design of regenerative hydrogels for immunomodulation in DFUs, are briefly introduced. Then, the potential immuno-therapeutic modalities of hydrogels and emerging trends used to treat DFUs via multitherapeutic approaches and enhanced efficacy and safety are discussed. Taken together, by linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future.

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Section: Hydrogels Alonementioning

confidence: 99%