Novel spectrophotometric methods for simultaneous determination of Amlodipine, Valsartan and Hydrochlorothiazide in their ternary mixture

Lotfy, Hayam M.; Hegazy, Maha A.; Mowaka, Shereen; Mohamed, Ekram H.

doi:10.1016/j.saa.2014.12.096

Cited by 47 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Derivative transformation [12], spectrum subtraction [13], amplitude factor [14], advanced absorbance subtraction method (AAS) [15], advanced amplitude modulation method (AAM) [15] and simultaneous derivative ratio (S 1 DD) [16] are well developed method that were successfully adopted for resolution of overlapped spectra of binary mixtures.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Mohamed

Lotfy

Hegazy

et al. 2017

Chemistry Central Journal

Self Cite

View full text Add to dashboard Cite

BackgroundAnalysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different novel and smart spectrophotometric techniques for resolution of severely overlapping spectra were presented in this work utilizing isosbestic points present in different absorption spectra, normalized spectra as a divisor and dual wavelengths. A quaternary mixture of drotaverine (DRO), caffeine (CAF), paracetamol (PCT) and para-aminophenol (PAP) was taken as an example for application of the proposed techniques without any separation steps. The adopted techniques adopted of successive and progressive steps manipulating zero /or ratio /or derivative spectra. The proposed techniques includes eight novel and simple methods namely direct spectrophotometry after applying derivative transformation (DT) via multiplying by a decoding spectrum, spectrum subtraction (SS), advanced absorbance subtraction (AAS), advanced amplitude modulation (AAM), simultaneous derivative ratio (S1DD), advanced ratio difference (ARD), induced ratio difference (IRD) and finally double divisor–ratio difference-dual wavelength (DD-RD-DW) methods.ResultsThe proposed methods were assessed by analyzing synthetic mixtures of the studied drugs. They were also successfully applied to commercial pharmaceutical formulations without interference from other dosage form additives. The methods were validated according to the ICH guidelines, accuracy, precision, repeatability, were found to be within the acceptable limits.ConclusionThe proposed procedures are accurate, simple and reproducible and yet economic. They are also sensitive and selective and could be used for routine analysis of complex most of the binary, ternary and quaternary mixtures and even more complex mixtures.

show abstract

Section: Theoretical Backgroundmentioning

confidence: 99%

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Mohamed

Lotfy

Hegazy

et al. 2017

Chemistry Central Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several methods have been proposed for the individual or simultaneous determination of hydrochlorothiazide with other pharmaceutical compounds including chemometry [7], spectroscopy [8][9][10][11], capillary electrophoresis [12,13], high performance liquid chromatography (HPLC) [14][15][16][17], time resolved chemiluminescence [18], liquid chromatography/tandem mass spectrometry [19,20], chemometry [21], and electrochemistry [22][23][24][25][26].…”

Section: Hydrochlorothiazidementioning

confidence: 99%

“…5B. Using this plot and the following equation [53], Epa=(RT/2HCTF) ln + constant (11) where Epa and HCT are the anodic peak potential and the electron transfer coefficient for the electrooxidation of hydrochlorothiazide, respectively, HCT was obtained as 0.41. In addition, the linear dependency of the anodic peak current on the square root of the potential sweep rate is presented in Fig.…”

Section: Electrocatalytic Oxidation Of Hydrochlorothiazide On Ncpementioning

confidence: 99%

Synthesis of nickel nanowrinkles and its application for the electrocatalytic oxidation and sensitive detection of hydrochlorothiazide

Heli

Pishahang

Amiri

et al. 2017

Microchemical Journal

View full text Add to dashboard Cite

Nickel nanowrinkles were synthesized by a simple hydrothermal method in one step in the presence of fluoride ions in ethylene glycol. The nanowrinkles were then employed as the modifier of a carbon paste electrode. The kinetics of the charge transfer across the modified electrode/solution interface was studied and the modified electrode was employed to fabricate an amperometric sensor of hydrochlorothiazide. The mechanism and kinetics of the electrocatalytic oxidation of hydrochlorothiazide on the modified electrode surface were studied by cyclic voltammetry and chronoamperometry. An amperometric procedure was developed for determination of hydrochlorothiazide with a sensitivity of 13.50 mA mol-1 dm 3 cm-2 and a limit of detection of 21.2 mol dm-3. The method was used for the direct assay of hydrochlorothiazide in human serum samples and hydrochlorothiazide tablets. The sensor had the advantages of sensitivity (guaranteed by a Nafion layer on the sensor surface), high electrocatalytic activity and long-term stability toward hydrochlorothiazide.

show abstract

“…AML and VAL are official in BP and USP [2,3]. Literature review showed that few analytical methods have been described for the estimation of AML and VAL including spectrophotometric [4][5][6][7], highperformance liquid chromatography (HPLC) [8][9][10][11][12][13][14], spectrofluorimetric method [15][16][17], electrochemical and voltammetric methods [18][19][20][21][22] had been reported for the estimation of AML and VAL in pure or in dosage forms. According to the best of my knowledge, there is no Stability indicating new-RP-HPLC method for simultaneous determination of Amlodipine Besylate, Valsartan and its related substances in their film-coated tablets dosage form.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Amlodipine Besylate, Valsartan, and Its Related Substances in Their Film-Coated Tablets Dosage form by RP-HPLC Method

2019

Adv. J. Chem. A

View full text Add to dashboard Cite

The current study aimed to develop and new, simple, accurate, economical and stability-indicating RP-HPLC for simultaneous estimation of Amlodipine Besylate, Valsartan and its related substances in their film-coated tablets dosage form. Chromatographic system was performed on the YMC ODS-A C18 (150 mm × 4.6 mm, 5μm particle size) using a binary gradient elution consist of two solvent systems, solution (A) 0.02 monobasic sodium phosphate Adjust with phosphoric acid to a pH of 2.5 and solution (B) consisting of Solution A: Acetonitrile (45:55). At a flow rate of 1.0 mL/min, injection volume 10 µL, UV detection at 235 nm, column oven temperature 30 ○ C and autosampler temperature 10 ○ C. This method was validated according to ICH requirements for new methods, which include accuracy, precision, selectivity, robustness, ruggedness, LOD, LOQ, linearity and range. Linear relationships were obtained in the ranges of 10-300 µg/mL and 5-200 µg/mL with correlation coefficients of 0.9997 and 0.9998 for Amlodipine Besylate and Valsartan respectively. The forced degradation studies as acidity, alkalinity, oxidation, heat, thermal, humidity and photodegradation were performed according to ICH guidelines. Amlodipine Besylate Valsartan Related substances RP-HPLC Dissolution Stability indicating method Tablet dosage form

show abstract

Novel spectrophotometric methods for simultaneous determination of Amlodipine, Valsartan and Hydrochlorothiazide in their ternary mixture

Cited by 47 publications

References 32 publications

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Synthesis of nickel nanowrinkles and its application for the electrocatalytic oxidation and sensitive detection of hydrochlorothiazide

Simultaneous Determination of Amlodipine Besylate, Valsartan, and Its Related Substances in Their Film-Coated Tablets Dosage form by RP-HPLC Method

Contact Info

Product

Resources

About