Novel Silver-NHC complexes: Synthesis and anticancer properties

Şahin‐Bölükbaşı, Serap; Şahin, Neslihan

doi:10.1016/j.jorganchem.2019.04.018

Cited by 37 publications

(24 citation statements)

References 31 publications

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“…These benzimidazolium salts were treated with silver oxide under dark condition to give silver−NHC complexes 115 a and b in the good yield of 83 % and 90 % respectively (Scheme 27). [66] …”

Section: Synthetic Strategiesmentioning

confidence: 99%

“…These benzimidazolium salts were treated with silver oxide under dark condition to give silverÀ NHC complexes 115 a and b in the good yield of 83 % and 90 % respectively (Scheme 27). [66] Aher et al synthesised methyl benzyl and nitrobenzyl containing imidazole-based silver NHC complexes 117 and 118. The ionic liquid 116 was treated with silver oxide in methanol for 24 hours.…”

Section: Silverà Nhc Complexesmentioning

confidence: 99%

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Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal‐based molecules. Among them, metal‐N‐heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal‐NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.

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Section: Synthetic Strategiesmentioning

confidence: 99%

Section: Silverà Nhc Complexesmentioning

confidence: 99%

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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“…Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1 . A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2 – 4 . Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Karadağ

Korkmaz

Aydın

et al. 2020

Sci Rep

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Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl)-ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten) 2 ] 2+ cations and [Ag(CN) 2 ] − anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1. A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2-4. Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5,6. For example, some macrocyclic polyamines containing Ni, Cu, and Ru could recognize TAR RNA molecules and cleave them, and affect the interaction of Tat-RNA 7. Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells.

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“…[5,12,13] Considering that a high number of organometallic compounds have emerged as promising anticancer drug candidates, the investigation of organometallic NHC complexes seems to be a logical next step. [5][6][7][8][9][10][11][12][13][14][15] Thus, it is hardly surprising that a score of M-NHC-based (M = Ag, Au, Pd etc.) biologically active compounds have been explored recently.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of these properties make them particularly interesting for the latter, namely in the development of novel classes of metallodrugs, in which strong metal‐ligand bonds that are robust toward dissociation are often a key problem , , . Considering that a high number of organometallic compounds have emerged as promising anticancer drug candidates, the investigation of organometallic NHC complexes seems to be a logical next step . Thus, it is hardly surprising that a score of M‐NHC‐based (M = Ag, Au, Pd etc.)…”

Section: Introductionmentioning

confidence: 99%

Expanding the Scope of Water‐Stable Rhenium(V)‐NHC Complexes – Synthesis, Characterization, and Derivatization

et al. 2019

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The synthesis of novel ReV–NHC oxo complexes bearing a tridentate scorpionate NHC ligand is reported. The complexes are accessible in a two‐step procedure from the precursor (NnBu4)[ReOCl4] by in situ deprotonation of the imidazolium salt 2,2‐bis(3‐methyl‐1H‐imidazol‐3‐ium‐1‐yl)acetate bromide (L1‐H2) using sodium hydride. The obtained complex [ReO(glyc)L1] (glyc = ethylene glycolato) is readily converted into [ReOCl2(L1)] which serves as starting material for the synthesis of water stable [ReO(L1)X] derivatives (X = dianionic ligand). In one case the formation of a Re dioxo species K2[ReO2(CN)2(L1)] was observed in aqueous conditions. All complexes were isolated, fully characterized and analyzed by XRD studies, demonstrating for the first time a coordination of scorpionate ligand L1 to rhenium. Additionally, their short‐ and long‐term stability in various aqueous media is an asset in view of developing new rhenium‐based metallodrugs.

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Novel Silver-NHC complexes: Synthesis and anticancer properties

Cited by 37 publications

References 31 publications

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Expanding the Scope of Water‐Stable Rhenium(V)‐NHC Complexes – Synthesis, Characterization, and Derivatization

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