Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Claudio‐Rizo, Jesús A.; Hernandez‐Hernandez, Nalleli G.; Cano-Salazar, Lucía F.; Flores‐Guía, Tirso E.; Cruz, Fabiola N. de la; Cabrera‐Munguía, Denis A.; Becerra‐Rodríguez, Juan J.

doi:10.1002/app.49739

Cited by 26 publications

(20 citation statements)

References 42 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increment in the reticulation index, as well as the generation of the IPN alginate-PU matrix, generates regions with crystal order characterized by resisting the thermal degradation requiring more heat to remove the short-range interactions such as intermolecular hydrogen bonds (associated with molecular entanglements) and crosslinking bonds, this is strong evidence for the characterization of an IPN system [35]. This improvement in resistance to thermal degradation is in accordance with the increment in the crystallinity and mechanical improvement, as has been reported in various works where other biopolymers are modified [24,25].…”

Section: Structural and Physicochemical Characterizationsupporting

confidence: 78%

“…The presence of crystalline phases in the prepared hydrogels was evaluated by WAXS, in Fig. 2b It has been shown that the generation of interpenetrating polymeric matrix systems generates regions with characteristic crystallinity, this is associated with the crosslinking, entanglement, and interpenetration interactions of polymeric agents producing regions with molecular order that can diffract X-rays [24,25,31]. Hydrogel systems based on IPN networks with crystalline regions provide sites with selective modulation in cellular processes optimizing the biological response in biomedical applications; cell-material interaction is important to regulate cell metabolism; in this way, cells that adhere to crystalline or amorphous surfaces would experience characteristic stimuli that affect their metabolism and secretion of important cytokines in the healing process [32]; this could be beneficial to favor the wound healing processes if these matrices are applied as wound healing dressings.…”

Section: Structural and Physicochemical Characterizationmentioning

confidence: 99%

“…According to the ASTM F 756-08, IPN materials are classified as non-hemolytic hydrogels, thus they could be easily applied to the wound beds, avoiding blood lysis. It has been reported that the interpenetration of biopolymers with this type of crosslinking agent increases the hemocompatibility of hydrogels developed for biomedical applications [24,25]. The flexible structure of PU and the ability it provides to the IPN matrix to absorb high amounts of water prevents the erythrocyte cell membranes from breaking, improving hemocompatibility.…”

Section: Studies Of In Vitro Biocompatibilitymentioning

confidence: 99%

“…It has been reported that the chemical structure of alginate prevents bacterial growth, therefore it is widely used in the food industry and in biomedical controlled release devices; this is mainly associated with the presence of Ca (II) ions and polysaccharide skeletons with a specific structural configuration that inhibits bacterial growth [44]. Other cellulose-derived polysaccharides such as starch have also provided the ability to inhibit bacterial growth in hydrogels for biomedical applications [24]. Furthermore, the use of this synthetic crosslinking agent in hydrogels based on semi-IPN collagen with polyacrylate has shown to provide the capacity to inhibit the growth of E. coli [25].…”

Section: Studies Of In Vitro Biocompatibilitymentioning

confidence: 99%

“…Furthermore, it has also been reported that these crosslinking agents allow the coupling with inorganic silica particles, providing the controlled release capacity of molecules with interest in biomedical applications [22,23]. In other words, the use of this crosslinking agent also allows the generation in an aqueous medium of semi-IPN hydrogels employing exogenous polymeric chains such as polyacrylate (PA) and cellulose derived polysaccharides, generating hydrogels with high biocompatibility, enhanced hemocompatibility, and antibacterial inhibition capacity [24,25].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Highly absorbent hydrogels comprised from interpenetrated networks of alginate–polyurethane for biomedical applications

Claudio‐Rizo

Escobedo-Estrada

Carrillo-Cortés

et al. 2021

J Mater Sci: Mater Med

Self Cite

View full text Add to dashboard Cite

Developing new approaches to improve the swelling, degradation rate, and mechanical properties of alginate hydrogels without compromising their biocompatibility for biomedical applications represents a potential area of research. In this work, the generation of interpenetrated networks (IPN) comprised from alginate–polyurethane in an aqueous medium is proposed to design hydrogels with tailored properties for biomedical applications. Aqueous polyurethane (PU) dispersions can crosslink and interpenetrate alginate chains, forming amide bonds that allow the structure and water absorption capacity of these novel hydrogels to be regulated. In this sense, this work focuses on studying the relation of the PU concentration on the properties of these hydrogels. The results indicate that the crosslinking of the alginate with PU generates IPN hydrogels with a crystalline structure characterized by a homogeneous smooth surface with high capacity to absorb water, tailoring the degradation rate, thermal decomposition, and storage module, not altering the native biocompatibility of alginate, providing character to inhibit the growth of E. coli and increasing also its hemocompatibility. The IPN hydrogels that include 20 wt.% of PU exhibit a reticulation index of 46 ± 4%, swelling capacity of 545 ± 13% at 7 days of incubation at physiological pH, resistance to both acidic and neutral hydrolytic degradation, mechanical improvement of 91 ± 1%, and no cytotoxicity for monocytes and fibroblasts growing for up to 72 h of incubation. These results indicate that these novel hydrogels can be used for successful biomedical applications in the design of wound healing dressings.

show abstract

Section: Structural and Physicochemical Characterizationsupporting

confidence: 78%

Section: Structural and Physicochemical Characterizationmentioning

confidence: 99%

Section: Studies Of In Vitro Biocompatibilitymentioning

confidence: 99%

Section: Studies Of In Vitro Biocompatibilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Highly absorbent hydrogels comprised from interpenetrated networks of alginate–polyurethane for biomedical applications

Claudio‐Rizo

Escobedo-Estrada

Carrillo-Cortés

et al. 2021

J Mater Sci: Mater Med

Self Cite

View full text Add to dashboard Cite

show abstract

Evolution of electrical conductivity in semi‐interpenetrating polymer network of shape memory polyvinyl chloride and polyaniline

Zou

Yang

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

Electrically conductive semi-interpenetrating polymer network (IPN) from shape memory polyvinyl chloride (PVC) and polyaniline (PANI) is realized. The mechanical properties and shape memory performance of semi-IPN are slightly different from the original PVC. The distribution of PANI within PVC is found to be non-uniform in the thickness direction. The electrical conductivity of the asfabricated sample at room temperature is around 4.5 Â 10 À2 S/cm. However, after heating, thermal strain results in significant drop in electrical conductivity. Programming remarkably reduces the electrical conductivity as well. A higher programming temperature and higher programming strain result in more reduction. Subsequent heating for shape recovery causes further reduction in electrical conductivity, despite nearly full shape recovery is achieved. Doping (dedoping and redoping) is confirmed not the major player, but microgaps/fracture in PANI chains during stretching in programming and heating for shape recovery.

show abstract

Smart hydrogels based on semi‐interpenetrating polymeric networks of collagen‐polyurethane‐alginate for soft/hard tissue healing, drug delivery devices, and anticancer therapies

et al. 2023

Self Cite

View full text Add to dashboard Cite

In this work, hydrogels based on semi‐interpenetrating polymeric networks (semi‐IPN) based on collagen‐polyurethane‐alginate were studied physicochemically and from different approaches for biomedical application. It was determined that the matrices in the hydrogel state are crosslinked by the formation of urea and amide bonds between the biopolymer chains and the polyurethane crosslinker. The increment in alginate content (0–40 wt%) significantly increases the swelling capacity, generating semi‐crystalline granular structures with improved storage modulus and resistance to thermal, hydrolytic, and proteolytic degradation. The in vitro bioactivity results indicated that the composition of these novel hydrogels stimulates the metabolic activity of monocytes and fibroblasts, benefiting their proliferation; while in cancer cell lines, it was determined that the composition of these biomaterials decreases the metabolic activity of breast cancer cells after 48 h of stimulation, and for colon cancer cells their metabolic activity decreases after 72 h of contact for the hydrogel with 40 wt% alginate. The matrices show a behavior of multidose release of ketorolac, and a higher concentration of analgesic is released in the semi‐IPN matrix. The inhibition capacity of Escherichia coli is higher if the polysaccharide concentration is low (10 wt%). The in vitro wound closure test (scratch test) results indicate that the hydrogel with 20 wt% alginate shows an improvement in wound closure at 15 days of contact. Finally, the bioactivity of mineralization was evaluated to demonstrate that these hydrogels can induce the formation of carbonated apatite on their surface. The engineered hydrogels show biomedical multifunctionality and they could be applied in soft and hard tissue healing strategies, anticancer therapies, and drug release devices.

show abstract

Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Cited by 26 publications

References 42 publications

Highly absorbent hydrogels comprised from interpenetrated networks of alginate–polyurethane for biomedical applications

Highly absorbent hydrogels comprised from interpenetrated networks of alginate–polyurethane for biomedical applications

Evolution of electrical conductivity in semi‐interpenetrating polymer network of shape memory polyvinyl chloride and polyaniline

Smart hydrogels based on semi‐interpenetrating polymeric networks of collagen‐polyurethane‐alginate for soft/hard tissue healing, drug delivery devices, and anticancer therapies

Contact Info

Product

Resources

About