Novel <scp>CT</scp> and scintigraphic findings of bone metastasis from invasive lobular breast cancer

Al-Ogaili, Zeyad; Troedson, Russell

doi:10.1111/1754-9485.12415

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…13 When slow-growing breast cancer cells infiltrate the bone marrow, they cause minimal osteoblastic responses, and owing to these responses small sclerotic lesions are formed. 14,15 Sclerotic metastases are relatively acellular with lower volume of tumour tissues and less bone destruction than lytic lesions. 16,17 The sensitivity of lesion detection by the radiology resident was 57.7% on patient-based analysis through original CT reading.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bone Reading CT software on radiologist performance in detecting bone metastases from breast cancer

Jeon

Bae

et al. 2017

BJR

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In patients with breast cancer, the use of Bone Reading application improved radiologist performance in bone metastasis detection compared with original chest CT reading with reduced reading time. This software will be more helpful to inexperienced radiologists for improving the reading performance. Advances in knowledge: Small and sclerotic lesions can be easily missed in original CT reading. Using Bone Reading CT software can enhance the performance of radiologists in detecting bone metastasis in breast cancer. False-negative rates can be significantly reduced in both inexperienced and experienced readers.

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Section: Discussionmentioning

confidence: 99%

Effect of Bone Reading CT software on radiologist performance in detecting bone metastases from breast cancer

Jeon

Bae

et al. 2017

BJR

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“…8,9 The nonadherent cancer cells in ILCs exhibit augmented migratory and invasive potential as evidenced by their infiltrative diffusion pattern observed within various anatomical sites, including breast tissue, serosal surfaces, meninges, gastrointestinal tract, and ovaries. 10,11 Due to distinctive molecular mechanisms and clinical characteristics, ILC poses a greater challenge compared with IDC in imaging detection, which encompasses mammography, ultrasound, MRI, bone scans, and 18 F-FDG PET/ CT. [12][13][14][15][16][17] Therefore, it is imperative to develop better imaging schemes for the assessment of local infiltration and distant metastasis in ILC.…”

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confidence: 99%

Can 18F-FES PET Improve the Evaluation of 18F-FDG PET in Patients With Metastatic Invasive Lobular Carcinoma?

Liu,

Ma,

et al. 2024

Clin Nucl Med

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Purpose Invasive lobular carcinoma (ILC) exhibits a low affinity for 18F-FDG. The estrogen receptor (ER) is commonly expressed in ILCs, suggesting a potential benefit of targeting with the ER probe 18F-FES in this patient population. The objective of this study was to evaluate the diagnostic performance of 18F-FES imaging in patients with metastatic ILC and compare it with that of 18F-FDG. Methods We conducted a retrospective analysis of 20 ILC patients who underwent concurrent 18F-FES and 18F-FDG PET/CT examinations in our center. 18F-FES and 18F-FDG imaging were analyzed to determine the total count of tracer-avid lesions in nonbone sites and their corresponding organ systems, assess the extent of anatomical regions involved in bone metastases, and measure the SUVmax values for both tracers. Results Among 20 ILC patients, 65 nonbone lesions were found to be distributed in 13 patients, and 16 patients were diagnosed with bone metastasis, which was distributed in 54 skeletal anatomical regions. The detection rate of 18F-FDG in nonbone lesions was higher than that of 18F-FES (57 vs 37, P < 0.001). 18F-FES demonstrated a superior ability to detect nonbone lesions in 4 patients, whereas 18F-FDG was superior in 5 patients (P > 0.05). Among 9/16 patients with bone metastasis, 18F-FES demonstrated a significant advantage in the detection of bone lesions compared with 18F-FDG (P = 0.05). Furthermore, patients with only 18F-FES–positive lesions (12/12) were administered endocrine regimens, whereas patients lacking 18F-FES uptake (2/3) predominantly received chemotherapy. Conclusions 18F-FES is more effective than 18F-FDG in detecting bone metastasis in ILC, but it does not demonstrate a significant advantage in nonbone lesions. Additionally, the results of examination with 18F-FES have the potential to guide patient treatment plans.

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Novel CT and scintigraphic findings of bone metastasis from invasive lobular breast cancer

Abstract: Osseous metastasis from ILC can have a characteristic imaging pattern on CT and SS. The pattern of USSL on CT scan with negative SS is highly suggestive of osseous metastasis from ILC.

Cited by 2 publications

References 12 publications

Effect of Bone Reading CT software on radiologist performance in detecting bone metastases from breast cancer

Effect of Bone Reading CT software on radiologist performance in detecting bone metastases from breast cancer

Can 18F-FES PET Improve the Evaluation of 18F-FDG PET in Patients With Metastatic Invasive Lobular Carcinoma?

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