Novel salts of the antiemetic drug domperidone: synthesis, characterization and physicochemical property investigation

Abstract

Domperidone (DOM) (6-chloro-3-[1-[3-(2-oxo-3H-benzimidazole-1-yl) propyl] piperidin-4-yl]-1H-benzimidazole-2-one) is an antiemetic, galactagogue and gastrokinetic that works by blocking the dopamine receptor D2. Due to its low solubility, it finds difficult to cross the...

Exploration and investigation of various solid forms of an anti-glaucoma drug – dichlorphenamide

“…The solubility/dissolution kinetics of the APIs can be influenced by a number of variables, including particle size, crystallinity percentage, hydration rate, and others. 35,36 It was anticipated that form II would demonstrate more solubility than the parent form I based on HS analysis, and these predictions are well supported by our solubility findings.…”

New drug–drug and drug–nutraceutical salts of anti-emetic drug domperidone: structural and physicochemical aspects of new salts

“…A literature search on DOM resulted in few salts with organic and inorganic acids. [42][43][44][45] Recently, the authors published various salts of DOM with improved solubility and dissolution. 46 DOM has a pK a value of 7.03 for piperidine nitrogen which facilitates the transfer of a proton from the coformers.…”