Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Mohan, Aarti; Narayanan, Shridhar; Sethuraman, Swaminathan; Krishnan, Uma Maheswari

doi:10.1155/2014/424239

Cited by 85 publications

(51 citation statements)

References 54 publications

(51 reference statements)

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“…They reported that 5-FU followed zero-order release kinetics, while Res followed the Higuchi model of diffusion. 41 Similar results have been reported in other studies with different nanoparticle formulations. 42,43 Stability studies PS, PdI, EEQ and EEP changes during 60 days of storage time are listed in Table 7.…”

Section: In Vitro Release Studysupporting

confidence: 88%

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Çelik¹,

Sagiroglu²,

Özdemir³

2017

IJN

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Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications.

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Section: In Vitro Release Studysupporting

confidence: 88%

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Çelik¹,

Sagiroglu²,

Özdemir³

2017

IJN

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“…On the contrary, the introduction of hydrophilic chains in the liposome surface favors greater entrapment of hydrophilic molecules when compared with hydrophobic molecules. 51 Drugs loaded in liposomes are not bioavailable; they only become bioavailable when they are released. Therefore, optimizing the release rate of a liposome-vehicle drug is strategic to reach a level within its therapeutic window and at a sufficient rate for a sufficient period to have optimal therapeutic activity.…”

Section: Liposomes As Nanocarriers For Drug Deliverymentioning

confidence: 99%

Liposomes as nanomedical devices

Bozzuto¹,

Molinari²

2015

IJN

1,669

1,080

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Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials.

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“…The results showed an increase in drug loading capacity and drug loading efficiency of the conjugate with glycine as compared to that without glycine; it was found out to 12.5% and 84.5% respectively [36]. [35].…”

Section: Resveratrolmentioning

confidence: 92%

Liposomes Containing Phytochemicals for Cancer Treatment-an Update

Khan

Suvarna

2016

Int J Curr Pharm Sci

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Many phytochemicals exhibit promising effects in treatment and prevention of various cancers, but due to their poor water solubility, stability, bioavailability and target specificity make administering them at therapeutic doses impractical. This is especially true for curcumin, quercetin, resveratrol and berberine. There is rising activity in developing nano drug delivery systems for these phytochemicals. These nano drug delivery systems mainly include liposomes, micelles, solid lipid nanoparticles, nanoemulsions, which are biocompatible and biodegradable nanoparticles. These nanoparticles can increase the stability and aqueous solubility of phytochemicals. They can also be used as sustained drug delivery systems. Much work has also proven that they enhance the absorption and bioavailability of the phytochemicals, protect them from premature enzymatic degradation or metabolism, hence prolonging their circulation time. Besides these parameters, in this review, we have also mentioned the improved target specificity of phytochemicals to cancer cells or tumours via passive or targeted delivery. Hence, nanotechnology cleared the way for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer.

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Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Cited by 85 publications

References 54 publications

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Liposomes as nanomedical devices

Liposomes Containing Phytochemicals for Cancer Treatment-an Update

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