Novel restricted access material combined to molecularly imprinted polymer for selective magnetic solid-phase extraction of estrogens from human urine

Oliveira, Hanna Leijoto de; Pires, Bruna Carneiro; Teixeira, Leila Suleimara; Dinali, Laíse Aparecida Fonseca; Simões, Nathália Soares; Borges, Warley de Souza; Borges, Keyller Bastos

doi:10.1016/j.microc.2019.104043

Cited by 40 publications

(4 citation statements)

References 54 publications

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“…The bands at 1270 cm −1 and 2980 cm −1 were attributed to the C-O and C-H, respectively. The absorption peak around 3525 cm −1 was related to the N-H stretching vibration of the amino group [30][31][32]. For CPE-MagMIP the band, characteristic of carbonaceous materials, was detected between 2900 cm −1 [33].…”

Section: Ft-ir Characterizationmentioning

confidence: 96%

Development of a Chemically Modified Electrode with Magnetic Molecularly Imprinted Polymer (MagMIP) for 17-β-Estradiol Determination in Water Samples

Silva

Pereira

2022

Electrochem

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The present work consisted of the development of an electrode based on carbon paste modified with magnetic molecularly imprinted polymer (CPE-MagMIP) for 17-β-estradiol (E2) detection. The incorporation of magnetic material (MagMIP) improved sensor performance, an increase of over 317%. The proposed method resulted in a linear response range from 0.5 to 14.0 μM, and the detection limit (LOD) and quantification limit (LOQ) were equal to 0.13 and 0.44 μM, respectively. Under optimized conditions, the developed sensor obtained satisfactory parameters in E2 determination in water samples, demonstrating selectivity, accuracy, and precision, making it a promising method for monitoring E2 in environmental samples.

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Section: Ft-ir Characterizationmentioning

confidence: 96%

Development of a Chemically Modified Electrode with Magnetic Molecularly Imprinted Polymer (MagMIP) for 17-β-Estradiol Determination in Water Samples

Silva

Pereira

2022

Electrochem

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“…Oliveira et al ( 2019a , 2019b ) in 2019 reported two new methods in different papers for successfully determination of estrogens such as estriol (E3) and estrone (E1) from human urine by Restricted Access Mesoporous Molecularly Imprinted Polymer double coated with Hydrophilic Monomer and Bovine Serum Albumin (RA-MMIP-HM-BSA/HPLC–UV) method and ethinylestradiol (EE2) and estradiol (E2) from human urine by Restricted Access Material combined to Molecularly Imprinted Polymer for selective Magnetic Solid-Phase Extraction (RAM-MIP-MSPE/HPLC–UV) method. The first developed method was linear for each hormone in the concentration range of 100–1100 ng mL −1 , with correlation coefficients of 0.9952 and 0.9954 for E3 and E1, respectively and the second improved technique produced linearity for each hormone across the concentration range of 80–1100 ng mL −1 , with correlation coefficients of 0.9954 and 0.9971 for E2 and EE2, respectively.…”

Section: Mip In Bioanalysismentioning

confidence: 99%

Recent molecularly imprinted polymers applications in bioanalysis

Suzaei¹,

Daryanavard

Abdel-Rehim

et al. 2022

Chem. Pap.

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Molecular imprinted polymers (MIPs) as extraordinary compounds with unique features have presented a wide range of applications and benefits to researchers. In particular when used as a sorbent in sample preparation methods for the analysis of biological samples and complex matrices. Its application in the extraction of medicinal species has attracted much attention and a growing interest. This review focus on articles and research that deals with the application of MIPs in the analysis of components such as biomarkers, drugs, hormones, blockers and inhibitors, especially in biological matrices. The studies based on MIP applications in bioanalysis and the deployment of MIPs in high-throughput settings and optimization of extraction methods are presented. A review of more than 200 articles and research works clearly shows that the superiority of MIP techniques lies in high accuracy, reproducibility, sensitivity, speed and cost effectiveness which make them suitable for clinical usage. Furthermore, this review present MIP-based extraction techniques and MIP-biosensors which are categorized on their classes based on common properties of target components. Extraction methods, studied sample matrices, target analytes, analytical techniques and their results for each study are described. Investigations indicate satisfactory results using MIP-based bioanalysis. According to the increasing number of studies on method development over the last decade, the use of MIPs in bioanalysis is growing and will further expand the scope of MIP applications for less studied samples and analytes.

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“…Unusual variations of free estrogens levels may be related to tumor growth, mainly postmenopausal. Oliveira et al [43] employed a magnetic-RAMIP covered with bovine serum albumin for the detection of estradiol and ethinylestradiol in urine samples. A polymer of methacrylic acid was formed at the surface of magnetic nanoparticles in the presence of estradiol (template).…”

Section: Hormonesmentioning

confidence: 99%

Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers

Silva

Tavares

Faria

et al. 2020

Critical Reviews in Analytical Chemistry

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Low concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.

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Novel restricted access material combined to molecularly imprinted polymer for selective magnetic solid-phase extraction of estrogens from human urine

Cited by 40 publications

References 54 publications

Development of a Chemically Modified Electrode with Magnetic Molecularly Imprinted Polymer (MagMIP) for 17-β-Estradiol Determination in Water Samples

Development of a Chemically Modified Electrode with Magnetic Molecularly Imprinted Polymer (MagMIP) for 17-β-Estradiol Determination in Water Samples

Recent molecularly imprinted polymers applications in bioanalysis

Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers

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