Novel renal biomarkers show that creatine supplementation is safe: a double-blind, placebo-controlled randomized clinical trial

Neto, José de Oliveira Vilar; Silva, Carlos Alberto da; Meneses, Gdayllon Cavalcante; Pinto, Daniel; Brito, Luciana Catunda; Fonseca, Said Gonçalves da Cruz; Alves, Renata de Sousa; Martins, Alice Maria Costa; Assumpção, Claudio de Oliveira; Daher, Elizabeth De Francesco

doi:10.1093/toxres/tfaa028

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…El propósito del presente estudio fue investigar el efecto a nivel renal de perfiles de consumo proteico para identificar los factores incidentes en la función renal en deportistas de CrossFit ® que tuvieran el objetivo de incrementar masa muscular, examinando los valores de BUN, Urea, CrS y TFG, que son parámetros ampliamente utilizados para la evaluación de la función renal (De Oliveira et al, 2020).…”

Section: Discussionunclassified

Identificación de Factores Asociados a la Ingesta Proteica Incidentes Sobre Función Renal en Deportistas de CrossFit®

González-González,

Rodriguez-Villa,

Fajardo Robledo

et al. 2023

ESJ

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Para aumentar la masa muscular, el CrossFit® ha sido relevante a la hora de ofrecer un ejercicio hipertrófico, aunque, el requerimiento proteico a consumir puede transformarse en excesivo. Las funciones renales activadas por la cantidad de metabolitos de degradación de proteínas se han asociado con procesos que desencadenan alteraciones renales. OBJETIVO: Identificar si el perfil de consumo proteico en deportistas de CrossFit® incide sobre la función renal. MATERIAL Y MÉTODO: En un período de cuatro meses, se registró el peso, altura, índice de masa corporal; dieta e información de suplementación proteica de 27 deportistas de CrossFit® voluntarios (23 hombres, 4 mujeres; edad promedio: 28.20 ± 3.60 años) en "Distrito Crossfit" (Jalisco, México). Se solicitaron estudios de Nitrógeno Ureico en Sangre, Urea y Creatinina Sérica, en "Salud Digna" (Jalisco, México), para determinar la tasa de filtración glomerular, con las fórmulas de Cockcroft-Gault, Modification of Diet in Renal Disease-4 y Mawer. Se compararon grupos de consumo alto versus normal por g/kg/d y mayor y menor consumo de 236.00 g/día, considerando la cantidad requerida para aumentar la masa muscular. RESULTADOS: Existieron disminuciones significativas (p<0.050) en la tasa de filtración glomerular con un alto consumo de 236.00 g/día y hubo un aumento significativo (p<0.050) de creatinina sérica en la suplementación durante más de un año, con una ingesta aumentada de 236.00 g/día, en comparación con aquellos con una ingesta adecuada sin suplementación. CONCLUSIÓN: El factor relevante para generar un efecto significativo en la filtración glomerular, es la cantidad y el tiempo de consumo de proteínas. To increase muscle mass, CrossFit® has been relevant in offering hypertrophic exercise, although the protein requirement to be consumed may become excessive. Renal functions activated by the amount of protein degradation metabolites have been associated with processes that trigger renal alterations. OBJECTIVE: To identify whether the protein intake profile in CrossFit® athletes affects renal function. MATERIALS AND METHODS: Over a period of four months, the weight, height, body mass index, diet, and protein supplementation information of 27 volunteer CrossFit® athletes (23 men, 4 women; average age: 28.20 ± 3.60 years) was recorded at "Distrito Crossfit" (Jalisco, México). Blood Urea Nitrogen, Urea, and Serum Creatinine studies were requested at "Salud Digna" (Jalisco, México) to determine glomerular filtration rate, with the Cockcroft-Gault, Modification of Diet in Renal Disease-4 and Mawer formulas. High versus normal intake groups were compared by g/kg/d and a higher and lower intake of 236.00 g/day, considering the amount required to increase muscle mass. RESULTS: There was a significant decrease (p<0.050) in the glomerular filtration rate with high a intake of 236.00 g/day and there was a significant increase (p<0.050) in serum creatinine on supplementation for more than one year with increased intake of 236.00 g/day compared to those with adequate intake without supplementation. CONCLUSION: The relevant factor to generate a significant effect on glomerular filtration is the amount and time of protein intake.

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Section: Discussionunclassified

Identificación de Factores Asociados a la Ingesta Proteica Incidentes Sobre Función Renal en Deportistas de CrossFit®

González-González,

Rodriguez-Villa,

Fajardo Robledo

et al. 2023

ESJ

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“…However, these values still fall within the normal range, and the elevated values compared to the baseline level can be explained by the fact that creatinine is a by-product of creatine metabolism. [12] Williamson et al made an interesting observation. In a study involving a physically active 42-year-old man, supplementation with creatine resulted in an elevated level of creatinine, which normalized after discontinuation of the supplement.…”

Section: Safety: Creatine Supplementation and Kidney Functionmentioning

confidence: 95%

Creatine - new hope in cancer treatment

Mądry,

Mazurkiewicz,

Marcicka

et al. 2024

J Educ Health Sport

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Introduction Creatine, a supplement popular especially among athletes, is gaining increasive attention from scientists worldwide due to its potential health benefits, among other things, in the context of its anti-cancer application. Materials and methods The following review of studies is based on scientific articles from recent years available in the PubMed and Google Scholar databases. Key search terms included: "creatine", "creatine supplementation", "creatine in sports", "supplementation in sports", "creatine in cancer”. Results The literature review unequivocally demonstrates the beneficial impact of creatine supplementation on numerous health and athletic aspects. Creatine has been observed to have a positive effect on selected aspects of cancer treatment, such as reducing tumor mass, complementing the action of commonly used anticancer drugs, and slowing down the wasting associated with cancer diseases. Conclusion The promising results of the cited studies indicate that further research into creatine supplementation and its mechanisms of action is necessary. There is a need for further research on the positive impact of creatine supplementation in the treatment of cancer diseases. The significant potential of creatine supplementation may enable its inclusion in clinical practice in the future and the development of an effective therapeutic strategy based on it in the treatment of cancer diseases.

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“…In the recent years, many research projects have been dedicated to the discovery of radiation and other environmental factors exposure biomarkers in blood samples or serum, such as many Life 2020, 10, 361 2 of 15 microRNAs [11][12][13][14][15][16] and proteins [17][18][19][20][21]. MicroRNA (miRNA) is non-coding small RNA comprised of approximately 20 bases and are a kind of classic negative regulator of gene expression.…”

Section: Introductionmentioning

confidence: 99%

A Biomarker Panel of Radiation-Upregulated miRNA as Signature for Ionizing Radiation Exposure

Song¹,

Xie²,

Gao³

et al. 2020

Life

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Ionizing radiation causes serious injury to the human body and has long-time impacts on health. It is important to find optimal biomarkers for the early quick screening of exposed individuals. A series of miRNAs signatures have been developed as the new biomarkers for diagnosis, survival, and prognostic prediction of cancers. Here, we have identified the ionizing radiation-inducible miRNAs profile through microarray analysis. The biological functions were predicted for the top six upregulated miRNAs by 4 Gy γ-rays: miR-1246, miR-1307-3p, miR-3197, miR-4267, miR-5096 and miR-7641. The miRNA-gene network and target gene-pathway network analyses revealed that DNAH3 is the target gene associated with all the six miRNAs. GOLGB1 is related to 4 miRNAs and other 26 genes targeted by 3 miRNAs. The upregulation of fifteen miRNAs were further verified at 4 h and 24 h after 0 to 10 Gy irradiation in the human lymphoblastoid AHH-1 cells, and some demonstrated a dose-dependent increased. Six miRNAs, including miR-145, miR-663, miR-1273g-3p, miR-6090, miR-6727-5p and miR-7641, were validated to be dose-dependently upregulated at 4 h or 24 h post-irradiation in both AHH-1 and human peripheral blood lymphocytes irradiated ex vivo. This six-miRNA signature displays the superiority as a radiation biomarker for the translational application of screening and assessment of radiation exposed individuals.

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Novel renal biomarkers show that creatine supplementation is safe: a double-blind, placebo-controlled randomized clinical trial

Cited by 4 publications

References 51 publications

Identificación de Factores Asociados a la Ingesta Proteica Incidentes Sobre Función Renal en Deportistas de CrossFit®

Identificación de Factores Asociados a la Ingesta Proteica Incidentes Sobre Función Renal en Deportistas de CrossFit®

Creatine - new hope in cancer treatment

A Biomarker Panel of Radiation-Upregulated miRNA as Signature for Ionizing Radiation Exposure

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