Novel reductive–reductive mode electrochemical detection of Rohypnol following liquid chromatography and its determination in coffee

Abstract

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Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods

“…Honeychurch et al. [ 153 ] developed LC-DED in a dual reductive mode for detecting flunitrazepam in coffee, and an LOD of 20 ng/mL was obtained, which was lower than the previous LC-ED method. A linear relationship was obtained in the range of 0.5–100 μg/mL ( R 2 = 0.9981).…”

Flavonoids in Selected Mediterranean Fruits: Extraction, Electrochemical Detection and Total Antioxidant Capacity Evaluation

“…RP‐HPLC‐ED offers the best selectivity and sensitivity, at nanomolar or even picomolar level detection limit, of electroactive compounds in complex matrices .…”

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

“…The same is true for the second upstream amperometric electrode, which will in turn convert only a fraction of the products generated by the first electrode. Nevertheless, such an approach has been shown to be successful for the determination of a number of benzodiazepines [20,21] and nitro aromatic compounds [22].…”