Novel quaternarized N-halamine chitosan and polyvinyl alcohol nanofibrous membranes as hemostatic materials with excellent antibacterial properties

Yin, Maoli; Wang, Yingfeng; Zhang, Yan; Ren, Xiaofeng; Qiu, Yinsheng; Huang, Tung‐Shi

doi:10.1016/j.carbpol.2019.115823

Cited by 120 publications

(47 citation statements)

References 65 publications

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“…In the spectrum of unmodified chitosan, the characteristic absorption bands at 3355, 3289 cm −1 (attributed to O–H and N–H stretching vibrations), 2869 cm −1 (CH stretching), 1651cm −1 (C=O stretching of amide I), 1550 cm −1 (N–H bending of amide II), 1151 cm −1 (C–O–C stretching), and 1062, 1027 cm −1 (C–O stretching) were observed ( Figure 4 a). The obtained spectrum is consistent with the literature data [ 55 , 56 ].…”

Section: Resultssupporting

confidence: 91%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide–dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox® test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.

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Section: Resultssupporting

confidence: 91%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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“…Various compounds such as metals [ 6 , 7 , 8 ] and metal oxides [ 9 , 10 ] in the form of the nanoparticles, antibiotics [ 11 , 12 , 13 ] or natural oil [ 14 ] can be used to modify chitosan for this purpose. A very effective modification consists in converting the amino groups of chitosan into quaternary salts of chitosan [ 15 , 16 , 17 , 18 , 19 , 20 ]. Such chitosan salts are characterized by the highly effective elimination of the various types of the microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…Others interesting biocidal agents are N -halamines, the halogen derivatives of the nitrogen (or ammonia), which are also used to modify chitosan. N -Halamines have been the subject of the intensive research in recent two decades [ 15 , 21 , 22 , 23 , 24 , 25 ]. These compounds can significantly differ their chemical structure—they may be aliphatic, aromatic, may contain Cl, Br or I and various other substituents, which affects both physical and chemical properties as well as their biologic activity and durability [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

N-Halamine Hydantoin-Containing Chitosan: Synthesis, Characterization, Thermal and Photolytic Stability Studies

Chylińska

Kaczmarek

2020

Molecules

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Current demand for new protective materials ensuring sterility is systematically growing. The purpose of this work was the synthesis of the biocidal N-halamine hydantoin-containing chitosan (CS-CMH-Cl) and characterization of its properties. The functionalization of the chitosan by 5-hydantoinacetic acid substitution leads to obtaining the CS-CMH polymer, which was chlorinated in next step to transform N-H into N-Cl bonds. In this study, the possibility of forming two biocidal N-Cl bonds in hydantoin ring, grafted onto chitosan chains, was proved. The structure and stability of the prepared material was confirmed by spectroscopic (FTIR, NMR, colorimetric test) and microscopic analyses (SEM, AFM). Surface properties were investigated based on contact-angle measurements. In addition, the thermal and photochemical stability of the obtained samples were determined as functional features, determining the range of potential use. It was found that both modified chitosan polymers (CS-CMH and CS-CMH-Cl) were characterized by the smaller thermal stability and more hydrophilic and rougher surface than unmodified CS. Photooxidative degradation of the obtained materials was observed mainly on the sample surface. After irradiation, the surfaces became more hydrophilic—especially in the case of the CS-CMH-Cl—which is advantageous from the point of view of the antibacterial properties. Antibacterial tests against S. aureus and E. coli confirmed the antibacterial activities of received CS-CMH-Cl material.

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“…Notably, this hemostasis foam could stop bleeding quickly without additionally external pressure. Yin et al (2020) synthesized a nanofibrous polyvinyl alcohol (PVA)/quaternary ammonium N-halamine chitosan (CSENDMH) membrane for the hemostasis dressing. This membrane with a bead-free network and porous structure exhibited a good water absorption and excellent blood clotting abilities for the effective hemostatic applications (Yin et al, 2020).…”

Section: Chitosanmentioning

confidence: 99%

“…Yin et al (2020) synthesized a nanofibrous polyvinyl alcohol (PVA)/quaternary ammonium N-halamine chitosan (CSENDMH) membrane for the hemostasis dressing. This membrane with a bead-free network and porous structure exhibited a good water absorption and excellent blood clotting abilities for the effective hemostatic applications (Yin et al, 2020). Zhang et al (2020) designed a composite sponge of hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) to improve the hemostatic effects (Figure 7).…”

Section: Chitosanmentioning

confidence: 99%

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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Rapid hemostasis and formation of stable blood clots are very important to prevent massive blood loss from the excessive bleeding for living body, but their own clotting process cannot be completed in time for effective hemostasis without the help of hemostatic materials. In general, traditionally suturing and stapling techniques for wound closure are prone to cause the additional damages to the tissues, activated inflammatory responses, short usage periods and inevitable second operations in clinical applications. Especially for the large wounds that require the urgent closure of fluids or gases, these conventional closure methods are far from enough. To address these problems, various tissue adhesives, sealants and hemostatic materials are placed great expectation. In this review, we focused on the development of two main categories of tissue adhesive materials: synthetic polymeric adhesives and naturally derived polysaccharide adhesives. Research of the high performance of hemostatic adhesives with strong adhesion, better biocompatibility, easy usability and cheap price is highly demanded for both scientists and clinicians, and this review is also intended to provide a comprehensive summarization and inspiration for pursuit of more advanced hemostatic adhesives for biological fields.

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Novel quaternarized N-halamine chitosan and polyvinyl alcohol nanofibrous membranes as hemostatic materials with excellent antibacterial properties

Cited by 120 publications

References 65 publications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

N-Halamine Hydantoin-Containing Chitosan: Synthesis, Characterization, Thermal and Photolytic Stability Studies

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

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