Novel production of natural bacteriocin via internalization of dextran nanoparticles into probiotics

Kim, Whee‐Soo; Han, Geon Goo; Hong, Liang; Kang, Seoung-Hun; Shokouhimehr, Mohammadreza; Choi, Yun‐Jaie; Cho, Chong‐Su

doi:10.1016/j.biomaterials.2019.119360

Cited by 26 publications

(22 citation statements)

References 46 publications

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“…Recently, emerging applications of nanotechnologies in prebiotics and probiotics have been developed and carried out as reported in Table 2 [154][155][156][157][158][159][160][161][162][163][164][165][166][167]. Table 2.…”

Section: Nano-prebiotics Nano-probiotics and Nano-synbioticsmentioning

confidence: 99%

“…The probiotics were internalized by phthalyl dextran nanoparticles (PDNs) to construct pediocin, aiming at the alteration of gut microbiome composition, the suppression of pathogenic intestinal infections, and the elevation of beneficial bacteria species [162] Antimicrobial effect…”

Section: Type Activity Study Referencesmentioning

confidence: 99%

“…Probiotics are indeed receiving special interest as an alternative to the classical antibiotics to overcome bacterial resistance. As prebiotics enhance the activity of probiotics, Kim et al [162] proposed the development of a prebiotic formulation composed of Pediococcus acidilactidi loaded in phthalyl dextran nanoparticles by conjugating phthalic anhydride with dextran [162]. The authors evaluated the cellular effects of the produced nanomaterial and checked the antimicrobial properties of the probiotics.…”

Section: Type Activity Study Referencesmentioning

confidence: 99%

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An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo

Nazhand

Lucarini

et al. 2020

IJMS

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Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved therapeutic/nutraceutical outcomes. The focus of this work is nanoprebiotics and nanoprobiotics, terms which stand for the loading of a set of compounds (e.g., prebiotics, probiotics, and synbiotics) in nanoparticles that work as absorption enhancers in the gastrointestinal tract. In this manuscript, the main features of prebiotics and probiotics are highlighted, together with the discussion of emerging applications of nanotechnologies in their formulation. Current research strategies are also discussed, in particular the promising use of nanofibers for the delivery of probiotics. Synbiotic-based nanoparticles represent an innovative trend within this area of interest. As only few experimental studies on nanoprebiotics and nanoprobiotics are available in the scientific literature, research on this prominent field is needed, covering effectiveness, bioavailability, and safety aspects.

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Section: Nano-prebiotics Nano-probiotics and Nano-synbioticsmentioning

confidence: 99%

Section: Type Activity Study Referencesmentioning

confidence: 99%

Section: Type Activity Study Referencesmentioning

confidence: 99%

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An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo

Nazhand

Lucarini

et al. 2020

IJMS

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“…The hydrophilic molecules that can be bonded with BODIPY, include polyethylene glycol (Kolate et al, ; W. Li, Zhan, De Clercq, Lou, & Liu, ; Lin et al, ; Yu Zhu et al, ), zwitterions (Debayle et al, ; Ji et al, ; Sinclair et al, ; Su et al, ), peptides (T. Li, Li, et al, ; Y. Sun, Liang, et al, ), dextran (Heo et al, ; W. S. Kim et al, ; Lv et al, ; Siewert et al, ), and so on. These hydrophilic compounds can reduce the negative effect of ions like NaCl in water on the stability of BDP NPs and increase blood circulation time of BDP NPs.…”

Section: Chemical Conjugationmentioning

confidence: 99%

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Lin

Colombani-Garay

Huang

et al. 2020

WIREs Nanomed Nanobiotechnol

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Boron dipyrromethene (BODIPY), as a traditional fluorescent dye, has drawn increasing attention because of its excellent photophysical properties like adjustable spectra and outstanding photostability. BODIPY dyes could be assembled into nanoparticles for cancer imaging and therapy via rational design. In this review, the bio‐applications of BODIPY‐containing nanoparticles are introduced in detail, such as cellular imaging, near‐infrared fluorescence imaging, computed tomography imaging, photoacoustic imaging, phototherapy, and theranostics. The construction strategies of BODIPY‐containing nanoparticles are emphasized so the review has three sections—self‐assembly of small molecules, chemical conjugation with hydrophilic compounds, and physical encapsulation. This review not only summarizes various and colorific bio‐applications of BODIPY‐containing nanoparticles, but also provides reasonable design methods of BODIPY‐containing nanoparticles for cancer theranostics. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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“…For instance, dextran-based polylactide (PLA) and 1,2-dipalmitoyl-snglycero-3-phosphoethanolamine (DPPE) nanoparticles (NPs) were developed for antitumor drug delivery (Wang et al 2012). Molecules with diverse chemical and structural properties can be encapsulated in a similar manner, including bacteriocin (Kim et al 2019); antisense oligonucleotides (Kiani et al 2016); anticancer drug, doxorubicin (Li et al 2013); antibiotics, amphotericin B (Tiyaboonchai and Limpeanchob 2007); and anti-rheumatic drug, methotrexate (Heo et al 2017). In addition to protective capabilities, biocompatibility and biodegradability of dextran-based polymers are also highly desirable in the drug delivery systems, to ensure minimum cytotoxicity and unwanted accumulation in organs.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic dextran-vinyl laurate-based nanoparticles: formation, characterization, encapsulation, and cytotoxicity on human intestinal cell line

et al. 2020

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Dextran has been the model material for the therapeutic applications owing to its biodegradable and biocompatible properties, and the ability to be functionalized in variety of ways. In this study, the amphiphilic dextran was successfully synthesized through lipase-catalyzed transesterification between dextran and vinyl laurate. In aqueous solution, the produced dextran ester could self-assemble into spherical nanoparticles ("Dex-L NPs") with approximately 200-nm diameter, and could incorporate porcine placenta hydrolysate with 60% encapsulation efficiency. Furthermore, Dex-L NPs exhibited low cytotoxic effects on human intestinal cell line and, thus, were potentially safe for oral administration. Taken together, the findings illustrate the potential of the newly developed nanoparticles to serve as an efficient and safe drug delivery system.

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Novel production of natural bacteriocin via internalization of dextran nanoparticles into probiotics

Cited by 26 publications

References 46 publications

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Amphiphilic dextran-vinyl laurate-based nanoparticles: formation, characterization, encapsulation, and cytotoxicity on human intestinal cell line

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