2020
DOI: 10.1111/cbdd.13768
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Novel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteria

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Cited by 3 publications
(8 citation statements)
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References 73 publications
(80 reference statements)
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“…To the original 25 mL round-bottom flask equipped with its magnetic stirring bar was added anhydrous DMF (3.0 mL) under nitrogen. The stirred mixture was cooled to 0 °C in an ice bath, and bromomethyl acetate (243 μL, 2.5 mmol, 2.5 equiv) was added dropwise. The reactant mixture was stirred for 30 min at 0 °C and then for an additional 12 h at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…To the original 25 mL round-bottom flask equipped with its magnetic stirring bar was added anhydrous DMF (3.0 mL) under nitrogen. The stirred mixture was cooled to 0 °C in an ice bath, and bromomethyl acetate (243 μL, 2.5 mmol, 2.5 equiv) was added dropwise. The reactant mixture was stirred for 30 min at 0 °C and then for an additional 12 h at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…The Gram-negative bacterium selected for this study, Pseudomonas aeruginosa, is opportunistic, exhibits multi-drug resistance, and has a pronounced propensity to form biofilms. The Gram-positive bacterium selected for this study, Staphylococcus epidermidis, has the ability to form biofilms and has been implicated in chronic urinary tract infections, as well as persistent infections on medical devices [26][27][28]. Staphylococcus epidermidis strain ATCC 35984 was chosen as a representative Grampositive organism with well-documented biofilm-forming ability.…”
Section: Biological Evaluationmentioning
confidence: 99%
“…The minimum inhibitory concentrations (MICs) of all compounds against S. epidermidis and P. aeruginosa were determined using a modified 96-well plate assay previously described by Walsh et. al., [26][27][28]. In short, Costar polystyrene 96-well plates were prepared with 150 µL of TSB and serial dilutions of the compound in dimethyl sulfoxide (DMSO).…”
Section: Microbiologymentioning
confidence: 99%
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“…In recent years, natural antimicrobial compounds have seemed to be suitable anti-QS and antibiofilm agents and many experiments determined the antimicrobial potential of many natural compounds against biofilm formation. Phenolic compounds have been shown to be effective in inhibiting the formation of biofilms and cell growth in pathogenic bacteria [ 19 ]. Moreover, these agents have shown modulatory effects on antibiotic resistance in S. aureus and S. epidermidis by inhibiting the function of efflux pumps, which are one of the important factors in biofilm maturation [ 20 ].…”
Section: Introductionmentioning
confidence: 99%