Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Edridge, Arthur W. D.; Deijs, Martin; Namazzi, Ruth; Cristella, Cosimo; Jebbink, Maarten F.; Maurer, Irma; Kootstra, Neeltje A.; Buluma, Linda Rosset; Woensel, Job B. M. van; Jong, Menno D. de; Idro, Richard; Hensbroek, Michaël Boele van; Hoek, Lia van der

doi:10.1093/cid/ciy486

Cited by 38 publications

(41 citation statements)

References 12 publications

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“…There has not been any other case of Ntwetwe virus from this region; hence, the case of this girl child was a rare and unique Pathogens 2020, 9,301 16 of 83 event. The study suggested that mosquitoes or an animal reservoir might be the probable source of transmission of this virus disease [74].…”

Section: Ugandamentioning

confidence: 98%

“…The patient went into a coma after two weeks of the onset of the disease. Diagnosis was carried out for the possible viral and bacterial diseases being circulated in the region but were negative [74]. Hence, cerebrospinal fluid (CSF) and plasma samples were used for viral metagenomic sequencing to investigate the possible etiological agent of the disease.…”

Section: Ugandamentioning

confidence: 99%

“…Hence, cerebrospinal fluid (CSF) and plasma samples were used for viral metagenomic sequencing to investigate the possible etiological agent of the disease. However, the bulk of the sequence could not identify a probable virus, but two short reads exhibited some similarity with several orthobunyavirus genome L-segments [74]. Therefore, the technique of genome walking was used to further extend these reads up to 936 nucleotides.…”

Section: Ugandamentioning

confidence: 99%

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Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

et al. 2020

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Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.

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Section: Ugandamentioning

confidence: 98%

Section: Ugandamentioning

confidence: 99%

Section: Ugandamentioning

confidence: 99%

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Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

et al. 2020

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“…This heterogeneity is expected when a new technology emerges but we agree that the studies illustrate the significant challenges of replicability and potentially validity of the findings; an area of particular concern when applied to human health. Further publication of previously undescribed viruses isolated from CSF have since emerged [16], in keeping with an exponential trend for the identification of novel pathogens using metagenomics [17*]. Further discussion of the limitations of the emerging trend for novel or unexpected pathogens is explored later.…”

Section: Sequencingmentioning

confidence: 99%

Advances in molecular diagnostic testing for central nervous system infections

Houlihan

Bharucha

Breuer

2019

Current Opinion in Infectious Diseases

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Purpose of review Central nervous system (CNS) infections present an ongoing diagnostic challenge for clinicians, with an aetiological agent remaining unidentified in the majority of cases even in high income settings. This review summarises developments in a range of diagnostic methods published in the past 18 months. Recent findings Several commercial assays exist for the detection of viral, bacterial and fungal pathogens using single multiplex PCR. Multicentre validation of the Biofire FilmArray panel illustrated high sensitivity for bacterial and fungal pathogens, but poor results for Cryptococcus species detection. The development of microarray cards for bacterial CNS pathogens shows promise but requires further validation. Few developments have been made in proteomics and transcriptomics, contrasted with significant increase in the use of metagenomic (or unbiased) sequencing. Novel viruses causing CNS infection have been described using this technique but contamination, cost, expertise and turnaround time requirements remain restrictive. Finally, the development of Gene Xpert and Ultra have revolutionised TB meningitis diagnostics with newly released recommendations for their use from the World Health Organisation.

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“…In the past decade, novel orthobunyaviruses associated with human and/or livestock diseases (Iquitos virus, Itaya virus, Ntwetwe virus, and Schmallenberg virus) have been identified. Furthermore, known orthobunyaviruses have re-emerged or expanded to new geographical territories, a situation that has presented a serious economic and public health threat (Aguilar et al, 2011;Wernike and Beer, 2017;Edridge et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Ebinur Lake Virus and Its Human Seroprevalence at the China–Kazakhstan Border

Xia

Liu²,

Zhao

et al. 2020

Front. Microbiol.

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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Cited by 38 publications

References 12 publications

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

Advances in molecular diagnostic testing for central nervous system infections

Characterization of Ebinur Lake Virus and Its Human Seroprevalence at the China–Kazakhstan Border

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