Novel non-invasive method of measurement of endothelial function: enclosed-zone flow-mediated dilatation (ezFMD)

Ukawa, Teiji; Takayanagi, T; Morimoto, Haruka; Higashi, Yukihito; Idei, Naomi; Yoshizumi, Masao; Tsuji, Toshio

doi:10.1007/s11517-012-0955-z

Cited by 9 publications

(12 citation statements)

References 16 publications

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“…Releasing this external pressure allows determination of the systolic and diastolic blood pressure, as pressures that correspond to stages of initiation and unimpeded flow of blood, respectively. Ambulatory blood pressure monitoring (6) based on this scheme requires an inflating cuff and oscillometric measurement (7,8). The possibility for tissue damage due to the repeated blocking of blood flow in such approaches limits the interval of measurement to between 15 min and 30 min (9, 10).…”

mentioning

confidence: 99%

Relation between blood pressure and pulse wave velocity for human arteries

Choi

Hourlier-Fargette

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

215

127

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Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens−Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.

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mentioning

confidence: 99%

Relation between blood pressure and pulse wave velocity for human arteries

Choi

Hourlier-Fargette

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

215

127

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“…Since FMD requires an expensive ultrasound system and high levels of technical skills, a novel method for measurement of endothelial function, namely, measurement of enclosedzone flow-mediated dilatation (ezFMD) was developed [133]. ezFMD is a noninvasive method which assesses the level of vasodilatation from the oscillation signals transmitted to a sphygmomanometer cuff attached to the upper arm.…”

Section: New Methods For Assessment Of Endothelial Function-measuremenmentioning

confidence: 99%

The Markers of Endothelial Activation

Drenjančević¹,

Jukić²,

Stupin³

et al. 2018

Endothelial Dysfunction - Old Concepts and New Challenges

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Biomarkers are biological indicators of processes that are part of ethiopathogenesis of the diseases, and can, but do not have to be causal to diseases. One very important question is how specific and sensitive the marker is, since one molecule can appear in many conditions. Biomarkers of endothelial cell activation can be very diverse, from biochemical/ metabolic to functional biomarkers. Activation of endothelial cells is part of physiological as well as pathophysiological response of cardiovascular system in conditions as physical activity, growth, pregnancy and in all cardiometabolic diseases (e.g., hypertension, diabetes mellitus, autoimmune inflammatory diseases, coronary artery disease, atherosclerosis, ischemia and reperfusion, etc.). During activation, there is a change in endothelial cell morphology and function, which could be a defensive response of endothelium to provoking factor or could lead to increased risk for the injury and end organ damage. This chapter aims to overview current knowledge on established biomarkers of normal and disease-related endothelial activation and to provide information on novel, potential biomarkers in common cardiometabolic diseases.

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“…It is therefore technically challenging to apply FMD testing to lower-limb arteries. With this in mind, the our research group proposed a novel method for determining the vascular endothelial function of upper-limb arteries easily without the use of an ultrasound device 11 – 13 . This technique, known as the enclosed zone FMD (ezFMD), involves the application of oscillometry (as used with commercial automated sphygmomanometers at patients’ homes and in hospitals) rather than vascular diameter measurement using an ultrasound device.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

Hirano

Takama

Matsumoto

et al. 2018

Sci Rep

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This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.

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Novel non-invasive method of measurement of endothelial function: enclosed-zone flow-mediated dilatation (ezFMD)

Cited by 9 publications

References 16 publications

Relation between blood pressure and pulse wave velocity for human arteries

Relation between blood pressure and pulse wave velocity for human arteries

The Markers of Endothelial Activation

Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

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