Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO 2  for biomedical applications

González-García, Dulce María; Téllez-Jurado, Lucía; Jiménez-Gallegos, Rodrigo; Rodríguez‐Lorenzo, Luís M.

doi:10.1016/j.msec.2017.02.041

Cited by 12 publications

(12 citation statements)

References 38 publications

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“…The maximum stress reached values obtained for the PEUs and PEUUs synthesized in this work were above those values, except for PEUU2000, which fell into that range. Since this is the value for the base material for manufacturing scaffolds, a decrease was expected for porous materials [6,38,39]. The better mechanical properties for PEUs were related to the phase separation of the soft and hard segment that involved a higher degree of physical crosslinking.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering

et al. 2018

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Two series of segmented polyurethanes were obtained and their mechanical and thermal properties as well as their biodegradability and cytotoxicity were evaluated. The chemical nature of the polyurethanes was varied by using either 1,4 butanediol (poly-ester-urethanes, PEUs) or l-lysine ethyl ester dihydrochloride (poly-ester-urea-urethanes, PEUUs) as chain extenders. Results showed that varying the hard segment influenced the thermal and mechanical properties of the obtained polymers. PEUs showed strain and hardness values of about 10–20 MPa and 10–65 MPa, respectively. These values were higher than the obtained values for the PEUUs due to the phase segregation and the higher crystallinity observed for the polyester-urethanes (PEUs); phase segregation was also observed and analyzed by XRD and DSC. Moreover, both series of polymers showed hydrolytic degradation when they were submerged in PBS until 90 days with 20% of weight loss. In vitro tests using a Human Osteoblastic cell line (Hob) showed an average of 80% of cell viability and good adhesion for both series of polymers.

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Section: Discussionmentioning

confidence: 99%

“…However, elastomers such as polyurethanes offer some unique advantages in terms of mechanical flexibility, tissue-biocompatibility, and tunable biodegradability. As a result, polyurethanes have been the most studied polymer in the biomedical field [6,7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering

et al. 2018

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“…Both the chemical nature of the starting components and their proportions determine the final set of PU material properties [13][14][15]. Another promising approach for adapting specific application properties offers the development of composite materials of PUs and inorganic fillers [16][17][18][19][20]. Concerning biodegradable PUs the formation of toxic degradation products arising from aromatic isocyanates is a major drawback for medical applications [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A Novel Resorbable Composite Material Containing Poly(ester-co-urethane) and Precipitated Calcium Carbonate Spherulites for Bone Augmentation—Development and Preclinical Pilot Trials

et al. 2020

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Polyurethanes have the potential to impart cell-relevant properties like excellent biocompatibility, high and interconnecting porosity and controlled degradability into biomaterials in a relatively simple way. In this context, a biodegradable composite material made of an isocyanate-terminated co-oligoester prepolymer and precipitated calcium carbonated spherulites (up to 60% w/w) was synthesized and investigated with regard to an application as bone substitute in dental and orthodontic application. After foaming the composite material, a predominantly interconnecting porous structure is obtained, which can be easily machined. The compressive strength of the foamed composites increases with raising calcium carbonate content and decreasing calcium carbonate particle size. When stored in an aqueous medium, there is a decrease in pressure stability of the composite, but this decrease is smaller the higher the proportion of the calcium carbonate component is. In vitro cytocompatibility studies of the foamed composites on MC3T3-E1 pre-osteoblasts revealed an excellent cytocompatibility. The in vitro degradation behaviour of foamed composite is characterised by a continuous loss of mass, which is slower with higher calcium carbonate contents. In a first pre-clinical pilot trial the foamed composite bone substitute material (fcm) was successfully evaluated in a model of vertical augmentation in an established animal model on the calvaria and on the lateral mandible of pigs.

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“…Besides obtaining better nanoparticles dispersion, the prepared urethane coatings showed improved mechanical properties and UV resistance. González-Garsía et al [17] reported obtained PUSN hybrid materials based on polyurethanes/TiO2 by a sol-gel process and investigated their potential applications in bone tissue regeneration. Prepared PUSNs represent biodegradable and non-cytotoxic hybrid materials, where the incorporated nano-filler enhanced thermal and mechanical features and promoted bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of poly(urethane-siloxane)/titanium-dioxide nanocomposites

Stefanović¹,

Dostanić²,

Lončarević³

et al. 2019

Hem Ind

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This work is focused on preparation of poly(urethane-siloxane)/titanium-dioxide nanocomposites (PUSNs) with enhanced features. PUSNs were prepared by the in situ polymerization reaction using titanium-dioxide as a nano-filler in different amounts (1, 2, 3 and 5 wt.%) with respect to the poly(urethane-siloxane) (PUS) matrix. PUS copolymer was based on α,ω-dihydroxy-ethoxypropyl-poly(dimethylsiloxane), 4,4'-methylenediphenyldiisocyanate and 1,4-butanediole. In order to investigate the influence of TiO2 content on the structure, UV resistance, thermal properties, hydrophobicity and morphology of the prepared PUSNs, FTIR spectroscopy, UV-Vis diffuse-reflectance spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), contact angle measurements, surface free energy (SFE) analysis, water absorption, scanning electron microscopy (SEM) and atomic force microscopy (AFM) were performed. The PUSNs showed excellent UV resistance, high hydrophobicity, low surface free energy and also higher thermal stability and rougher surface and cross-section relief structure as compared to the pure PUS copolymer. Based on the obtained results it can be concluded that prepared PUSNs could be potentially used as protective coatings.

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Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO 2 for biomedical applications

Cited by 12 publications

References 38 publications

Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering

Synthesis and in Vitro Cytocompatibility of Segmented Poly(Ester-Urethane)s and Poly(Ester-Urea-Urethane)s for Bone Tissue Engineering

A Novel Resorbable Composite Material Containing Poly(ester-co-urethane) and Precipitated Calcium Carbonate Spherulites for Bone Augmentation—Development and Preclinical Pilot Trials

Preparation and characterization of poly(urethane-siloxane)/titanium-dioxide nanocomposites

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