Novel Natural Products from Marine Sea Stars

Banu, N

doi:10.19080/ctbeb.2017.02.555592

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Crude and fractioned ethanolic, n-butanol and methanolic extracts of the sea stars Luidia maculate, Stellaster equestris, Astropecten indicus, Protoreaster lincki, Pentaceraster regulus demonstrate antibacterial and antifungal activity against human pathogens. Although only few biologically active substances were identified and isolated, the marine sea star Echinoderm is considered as an exceptional source of polar steroids with large structural diversity showing a wide range of bioactivities [71].…”

Section: Anti-biofilm Agents From Sea Starsmentioning

confidence: 99%

Anti-biofilm agents from marine biota

G. Vladkova,

L. Martinov,

N. Gospodinova

2023

JCTM

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Microbial biofilm forms on any living or non-living material surface contacting with microbial species. It is a persistent world-weight spread problem with very high prize. This explains the exclusive interest to development of anti-biofilm material surfaces. The continuously increasing microbial resistance to currently used antimicrobial agents requires looking for new ones. Marine biota is a rich source of biologically active substances with anti-biofilm potential that is scarily studied.The aim of this review is to outline the variety of marine sources delivering antimicrobial agents and their ability to inhibit different stages of the biofilm development, expecting to give some ideas for their utilization in the creation of improved antibiofilm material surfaces.It includes short information about the negative impact and cost, mode of development and composition of the microbial biofilms, as well as principle approaches to the inhibition with focus on the sources of biologically active substances and anti-biofilm agents from marine biota.The main conclusion is that the antibiofilm activity of many marine biota derived biologically active substances is not enough investigated although their strong bactericidal, antioxidant, surfactant and other activities are already proved and utilized in the medicine, cosmetic, food industry and others. This review is an update of the known to day on the marine sources derived anti-biofilm agents.

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Section: Anti-biofilm Agents From Sea Starsmentioning

confidence: 99%

Anti-biofilm agents from marine biota

G. Vladkova,

L. Martinov,

N. Gospodinova

2023

JCTM

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In vitro Antimicrobial Evaluation of an Isolated Compound from Sea Star Stellaster Equisteris

Sumitha

Dharshana

Banu

et al. 2022

Biomed. Pharmacol. J.

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Natural biomedical metabolites procured from marine sources have been the sole source of recent research. The antimicrobial resistance to human infections has made a mounting need for novel natural antibiotics. Much explored marine invertebrates largely the echinoderms (sea stars) tend to pose a natural innate mechanism to safeguard them against predators. The sea star secretes antimicrobial peptides which are naturally occurring secondary metabolites that possess a broad spectrum of antimicrobial susceptibility against bacteria, fungi, and viruses. The present study centers on the aspects of isolation and evaluation of active bioactive metabolite from the echinoderm Stellaster equestris from the Chennai coast. The whole body was utilized for the extraction using non-polar to polar solvents. The active crude extracts were investigated by qualitative assay for their chemical composition and were purified by column chromatography. The purity of the compound was further analyzed and checked for purity and quantified by the High-pressure liquid chromatography. The defined concentration of the isolated and purified compound from sea star Stellaster equestris (50,100, 150, 200, 250 and 300µg/ml) were subjected for antimicrobial sensitivity by well diffusion method and Tube dilution method. The outcome of the present study indicated the active crude extract from the sea star Stellaster equestris was rich in sterols. The evaluation of antimicrobial susceptibility by tube dilution and well diffusion assay indicated that the isolated purified compound from the sea star Stellaster equestris was reported to be evident for all the above-mentioned concentrations by a marked zone of clearance. A dose-dependent increase was observed in the tube dilution method. Therefore compounds possess antimicrobial activity and can be further subjected for developing the compound as a potent antimicrobial drug.

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Antiparasitic activity of Ophiocomina nigra in Entamoeba invadens

Sánchez-Ramos

Valdés-Santiago

Domínguez

et al. 2019

EJPG

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Objetive: Analyze the antiparasitic activity of marine invertebrate Ophiocomina nigra in Entamoeba invadens. Methodology. In O. nigra, an analysis of the quantitative proximal chemical composition (moisture, ash, protein, lipids and nitrogen-free extract) was performed. In addition, the determination of the total protein pattern (SDS-PAGE 10%). On the other hand, the antiparasitic activity of E. invadens trophozoites was determined, which were grown in TYI medium at 28 ° C and exposed to the aqueous extract of O. nigra for 24 hours. Subsequently, metabolic activity (XTT assay) was determined and morphology was analyzed. Cytotoxicity tests were performed on human liver cells (Hep G2) exposed for 24 hours to O. nigra (XTT test) and the biomass was determined (violet crystal staining). Contribution. The antiparasitic activity of O. nigra in E. invadens and the cytotoxic effect in human liver cells was determined. There are few scientific studies of this marine invertebrate on its use in traditional medicine, so it is important to analyze its effects and therapeutic value.

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Novel Natural Products from Marine Sea Stars

Cited by 3 publications

References 19 publications

Anti-biofilm agents from marine biota

Anti-biofilm agents from marine biota

In vitro Antimicrobial Evaluation of an Isolated Compound from Sea Star Stellaster Equisteris

Antiparasitic activity of Ophiocomina nigra in Entamoeba invadens

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