Novel Nanotechnology Based Delivery Systems for Chemotherapy and Prophylaxis of Tuberculosis

Jain, Rajesh; Savla, Hemali; Naik, Isha; Maniar, Jinesh; Punjabi, Kapil; Vaidya, Shashikant; Menon, Mala

doi:10.1016/b978-0-12-813351-4.00034-1

Cited by 6 publications

(2 citation statements)

References 116 publications

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“…[ 32 ] EGaIn‐β‐ala@Au had the smallest particle size distribution; while, the polydispersity Index (PDI) of the nanoparticle was the largest (more than 0.4), which indicates inhomogeneity of the particles. [ 33 ] EGaIn‐PAP@Au showed increased particle size and PDI than other EGaIn‐ p ‐aniline‐R@Au (Figure 2a), suggesting that PAP functionalized nanoparticles were prone to aggregate. The zeta potential of the nanoparticles ranged from 40 to 50 mV (Figure S4, Supporting Information), and the EGaIn‐PPD@Au had the highest surface charge with the highest homogeneity of distribution and the lowest PDI.…”

Section: Resultsmentioning

confidence: 99%

Ligand Mediation for Tunable and Oxide Suppressed Surface Gold‐Decorated Liquid Metal Nanoparticles

Huang,

Guan,

Bao

et al. 2023

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Gallium‐based liquid metal systems hold vast potential in materials science. However, maximizing their possibilities is hindered by gallium's native oxide and interfacial functionalization. In this study, small‐molecule ligands are adopted as surfactants to modify the surface of eutectic gallium indium (EGaIn) nanoparticles and suppress oxidation. Different p‐aniline derivatives are explored. Next, the reduction of chloroanric acid (HAuCl4) onto these p‐aniline ligand modified EGaIn nanoparticles is investigated to produce gold‐decorated EGaIn nanosystems. It is found that by altering the concentrations of HAuCl4 or the p‐aniline ligand, the formation of gold nanoparticles (AuNPs) on EGaIn can be manipulated. The reduction of interfacial oxidation and presence of AuNPs enhances electrical conductivity, plasmonic performance, wettability, stability, and photothermal performance of all the p‐aniline derivative modified EGaIn. Of these, EGaIn nanoparticles covered with the ligand of p‐aminobenzoic acid offer the most evenly distributed AuNPs decoration and perfect elimination of gallium oxides, resulting in the augmented electrical conductivity, and highest wettability suitable for patterning, enhanced aqueous stability, and favorable photothermal properties. The proof‐of‐concept application in photothermal therapy of cancer cells demonstrates significantly enhanced photothermal conversion performance along with good biocompatibility. Due to such unique characteristics, the developed gold‐decorated EGaIn nanodroplets are expected to offer significant potential in precise medicine.

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Section: Resultsmentioning

confidence: 99%

Ligand Mediation for Tunable and Oxide Suppressed Surface Gold‐Decorated Liquid Metal Nanoparticles

Huang,

Guan,

Bao

et al. 2023

Small

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“…More importantly, they enable longer circulation of bioactive compounds in blood and higher accumulation in tissues, cells and organs [ 89 ]. The particle size of polymeric NPs ranges from 10–1000 nm and are composed of either natural polymer such as chitosan, gelatin, casein, κ-carrageenan, sodium alginate, albumin and heparin or synthetic polymers such as polyethylene glycol, poly-L-lactic acid, polycaprolactone, poly (alkyl cyanoacrylate) and N -(2-hydroxypropyl)-methacrylamide [ 90 , 91 ]. Among various biopolymers used for preparation of polymeric NPs, chitosan, a cationic natural polysaccharide, is the most commonly used natural polymer owing to its cross-linking capacity and ability to provide sustained release of encapsulated bioactive compounds [ 92 ].…”

Section: Preparation Physicochemical Characterization Stability Evaluation and Biological Activitymentioning

confidence: 99%

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

2021

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Carotenoids are natural pigments widely used in food industries due to their health-promoting properties. However, the presence of long-chain conjugated double bonds are responsible for chemical instability, poor water solubility, low bioavailability and high susceptibility to oxidation. The application of a nanoencapsulation technique has thus become a vital means to enhance stability of carotenoids under physiological conditions due to their small particle size, high aqueous solubility and improved bioavailability. This review intends to overview the advances in preparation, characterization, biocompatibility and application of nanocarotenoids reported in research/review papers published in peer-reviewed journals over the last five years. More specifically, nanocarotenoids were prepared from both carotenoid extracts and standards by employing various preparation techniques to yield different nanostructures including nanoemulsions, nanoliposomes, polymeric/biopolymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid nanoparticles, supercritical fluid-based nanoparticles and metal/metal oxide nanoparticles. Stability studies involved evaluation of physical stability and/or chemical stability under different storage conditions and heating temperatures for varied lengths of time, while the release behavior and bioaccessibility were determined by various in vitro digestion and absorption models as well as bioavailability through elucidating pharmacokinetics in an animal model. Moreover, application of nanocarotenoids for various biological applications including antioxidant, anticancer, antibacterial, antiaging, cosmetics, diabetic wound healing and hepatic steatosis were summarized.

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Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method

Nguyen

Huynh

et al. 2021

IFMBE Proceedings

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Novel Nanotechnology Based Delivery Systems for Chemotherapy and Prophylaxis of Tuberculosis

Cited by 6 publications

References 116 publications

Ligand Mediation for Tunable and Oxide Suppressed Surface Gold‐Decorated Liquid Metal Nanoparticles

Ligand Mediation for Tunable and Oxide Suppressed Surface Gold‐Decorated Liquid Metal Nanoparticles

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method

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