Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method

Nguyen, Mai Chau-Ngoc; Le, Khoa Nguyen-Manh; Huynh, Ngan Thi-Thu; Nguyen, Tham Thi-Thanh; Bui, Hoa Thi-Xuan; Nguyen, Van Hong

doi:10.1007/978-3-030-75506-5_25

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Therefore, searching for novel methods to improve the absorption of BBR in the gut might be beneficial for the treatment of cancer. Previous studies have suggested complexation with C60 fullerene ( 200 ), solid lipid nanoparticles (SLNs) encompassing BBR by the spray-drying method ( 201 ), combining it with p-gp inhibitors (such as tariquidar and tetrandrine) ( 196 , 198 ), and modification to berberine organic acid salts (BOAs) ( 168 ). However, the above-mentioned strategies were mostly tested in animals and must be demonstrated in human clinical trials.…”

Section: Colorectal Cancermentioning

confidence: 99%

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Jiang

et al. 2022

Front. Med.

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Colorectal cancer (CRC) is one of the most commonly diagnosed and deadly malignancies worldwide. The incidence of CRC has been increasing, especially in young people. Although great advances have been made in managing CRC, the prognosis is unfavorable. Numerous studies have shown that berberine (BBR) is a safe and effective agent presenting significant antitumor effects. Nevertheless, the detailed underlying mechanism in treating CRC remains indistinct. In this review, we herein offer beneficial evidence for the utilization of BBR in the management and treatment of CRC, and describe the underlying mechanism(s). The review emphasizes several therapeutic effects of BBR and confirms that BBR could suppress CRC by modulating gene expression, the cell cycle, the inflammatory response, oxidative stress, and several signaling pathways. In addition, BBR also displays antitumor effects in CRC by regulating the gut microbiota and mucosal barrier function. This review emphasizes BBR as a potentially effective and safe drug for CRC therapy.

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Section: Colorectal Cancermentioning

confidence: 99%

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Jiang

et al. 2022

Front. Med.

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show abstract

Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method

Cited by 1 publication

References 27 publications

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

Berberine as a Potential Agent for the Treatment of Colorectal Cancer

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