Novel N-thioamide analogues of pyrazolylpyrimidine based piperazine: Design, synthesis, characterization, in-silico molecular docking study and biological evaluation

Synthesis and antimicrobial/antioxidant evaluation of novel pyrimidine-based derivatives with pendant pyrazoles using vinamidinum salts

“…Antibacterial and antifungal potentials of pyrazolylpyrimidines (7a-f) were investigated on pathogenic strains and compared with those of ceftriaxone and ketoconazole (Table 1). Antibacterial, antifungal, antimalarial and antituberculosis activities of some N-thiomide analogues of ethyl 5-methyl-1-(6-(piperazin-1-yl)pyrimidin-4-yl)-1H-pyrazole-4-carboxylate were studied against a variety of microorganisms [39]. The minimum inhibitory concentrations (MICs) were in the range of 25-1000 μg.ml -1 .…”

Interpol review of controlled substances 2016–2019

“…Piperazines: 2016 HPLC-MS method to determine the trace residues of piperazine [ 1141 ]; HPLC method for characterizing of impurities (1-[4-[(2,4-dimethylphenyl)thio]phenyl]-piperazine) in vortioxetine confirmed by LC-MS, IR and NMR [ 1142 ]; HPLC-FLD method for determination of piperazine residues [ 1143 ]; synthesis of Sodium4-benzyl piperazine-1-carbodithioate and sodium4-benzhydryl piperazine-l-carbodithioate and characterization by FT-IR and multinuclear NMR (H-1, C-13) spectroscopy [ 1144 ]; 2017 GC-EI/MS/MS for determination of piperazine [ 1145 ]; UPLC-ESI/MS/MS) method for the detection of piperazine [ 1146 ]; 2019 spectral analysis of novel N-thioamide analogues of pyrazolylpyrimidine based piperazine using Mass, H-1 NMR and C-13 NMR spectral techniques [ 1147 ];…”

Synthesis, Kinetics and Computational Explorations of 4‐Phenylpiperazine Bearing N‐(Aryl)‐3‐substituted‐benzamides as Auspicious Tyrosinase Inhibitors

“…The piperazine ring, naturally contains two nitrogen atoms at opposite positions, is widely existed in numerous biologically active compounds. [1] The piperazine scaffold in drug discovery, has been putative as a core structure and is extensively adhered in biologically active compounds employed in several therapeu-tic fields, including antitumor, [2] antibacterial, [3] antipsychotic, [4][5] anti-Alzheimer, [6][7][8] antifungal, [9] and antidiabetics. [10] Between two nitrogen of piperazine core, the N-4 nitrogen of ring acted as a nucleophilic site while the N-1 nitrogen simply introduces hydrophobic groups and hydrogen bond acceptors without imposing a stereocenter.…”

“…The piperazine ring, naturally contains two nitrogen atoms at opposite positions, is widely existed in numerous biologically active compounds [1] . The piperazine scaffold in drug discovery, has been putative as a core structure and is extensively adhered in biologically active compounds employed in several therapeutic fields, including antitumor, [2] antibacterial, [3] antipsychotic, [4–5] anti‐Alzheimer, [6–8] antifungal, [9] and antidiabetics [10]…”