Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides: synthesis, cytotoxicity, anticancer activity, COMPARE analysis and docking

Quinazoline pharmacophore in therapeutic medicine

“…A series of quinazoline prepared via Schiff bases formation were screened against herpes simplex virus-1 (KOS), virus-2 (G) and vaccinia virus (Ali et al, 2007), wherein (E)-3-((2-hydroxybenzylidene) amino)-2-phenyl quinazolin-4 (3H)-one emerged as the most promising antiviral motif against the entire tested virus . It has also been reported that high indicator of the antiviral activity of N-methyl-2-((2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio)acetamide (Kolavenko et al, 2013) bearing-adamantane against influenza type A H3N2 was due to insertion of carcass amine.…”

Synthesis and antiviral activity of [(9-R1-10-R2-3-R-2-oxo-2H-[1,2,4]-triazino[2,3-c]quinazolin-6-yl)thio]acetamides derivatives with the fragments of carcass amines

“…Following the strategy mentioned we decided to combine the carcass amine fragment with the planar [1,2,4]-riazino [2,3-с]quinazoline system, and it, in our opinion, yielded the compounds with a high antiviral activity. Our expectations also encouraged by the proved anticancer activity among substituted [1,2,4]-triazino[2,3-с]quinazolines [8,9,10]. So, our work was aimed at the synthesis of…”

Synthesis and Biological Activity of Some New 1,2,4-Triazino[6,1-B]quinazoline Derivatives.

“…In addition 1,2,4-triazine derivatives were found to possess antimicrobial activity (Taha M.A.M., 2007 andElsilk et al, 2010), antitumor activity (Gucky´ et al, 2010). Finally,condensed [1,2,4]triazinoquinazoline were reported to have antibacterial and antifungal activity (Abdel-Mageed et al, 1988;Abdel-Hamide et al, 1997;Abdel-Hamide, 2001;Ghorab et al 2013), anti-inflammatory activity (Bansal et al, 2001 andHussein, 2012), anticancer activity (Kovalenko et al 2013) and analgesic activity (Pathak et al 1995).…”