Novel methotrexate prodrug-targeted drug delivery system based on PEG–lipid–PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C

Abstract

Lipid–MMC in cooperation with pegylated lipid–MTX based on PEG–PE–PLA hybrid NPs can coordinate an early-phase targeting effect with a late-phase anticancer effect.

Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics

“…On the other hand, the cytotoxicity of MTX-MagTSLs against HeLa cells was higher than treated with free Dox, and MTX-MagTSLs induced more potent cytotoxicity than MagTSLs against HeLa cells, but smaller trend against A549 cells. Such a cytotoxicity difference revealed that MTX could be used to enhance cytotoxic effect selectively ascribed to folate receptor targeting ability and intrins ic toxicity, which was in agreement with the previous reports [21]. 8C).…”

“…Besides acting the role of anticancer drug, MTX also has a good targeting effect to folate receptor-overexpressed cancer cells such as human cervical carcinoma (HeLa) cells, due to the similar structure with folate [17][18][19][20]. MTX can be connected to phospholipid molecules through amide reaction for functionalization of TSLs, which introduce folate receptor-mediated active targeting strategy in the treatment of cancer [21]. Although several targeting strategies have been developed in recent decades, the folate receptor-mediated active targeted delivery is still limited by the insufficient drug release at tumor site, which can be improved by local temperature-triggered drug release from the TSLs [22][23][24].…”

Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin

“…PLA is a biodegradable and biocompatible polymer, which is widely used in the realms of drug delivery, bioengineering, and so on [14,15,16,17]. However, the high hydrophobicity, low drug loading efficiency, and long degradation time have limited the biomedical application of PLA [18].…”

Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy

“…Nanosized drug carriers were emerging platforms for cancer therapy because of their unique ability to increase the water solubility and stability, improve the pharmacokinetic profile, prolong the circulation time, and promote the enrichment and accumulation of the drug in the tumor tissue because of the enhanced permeability and retention (EPR) effect. 10,[37][38][39] Recently, polymeric micelles with a nanoparticle structure, self-assembled from biocompatible and biodegradable amphiphilic block polymers, have attracted increasing attention as drug carriers for anticancer drug. 24,29,30 In addition, compared to delivering a single type of drug, simultaneously delivering multiple types of drugs with disparate physiochemical characteristics, distinct pharmaceutical pathways, and different anticancer mechanisms to the same tumor cells using a single kind of nanosized drug carriers could achieve the additional or synergistic therapeutic effects by overcoming the drug resistance of cancer cells to one type of chemotherapeutic drug as well as reducing the serious side effects and limited regime of clinical use.…”