Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy

Lin, Jun; Li, Yang; Wu, Hongjie; Yang, Xiangrui; Li, Yanxiu; Ye, Shefang; Hou, Zhenqing; Lin, Cuiying

doi:10.1039/c4ra14602f

Cited by 11 publications

(10 citation statements)

References 49 publications

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“…The result of in vitro cell viability study presented that the MMC/HCPT loaded FA-micelles demonstrated time-and concentration-dependent cytotoxicity. The cytotoxicity of combined drugs is significantly enhanced compared to both the free drugs and necessarily deters tumour growth than free drugs 65 as represented in Figure 5. MMC-SPC complex loaded phytosomes (MMC-loaded phytosomes) as drug carriers were surfacemodified with folate-PEG (FAPEG) to attain reduced toxicity and a superior MMC mediated therapeutic effect.…”

Section: Mitomycin Cmentioning

confidence: 94%

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

et al. 2017

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Nanotechnology offers a number of nanoscale implements for medicine. Among these, nanoparticles are revolutionizing the field of drug and gene delivery. Chitosan is a natural polymer which provides a profitable tool to an innovative delivery system due to its inherent physicochemical and biological characteristics. Chitosan nanoparticles are promising drug and gene delivery carriers because of small size, better stability, low toxicity, inexpensiveness, simplicity, easy fabrication and versatile means of administration. Chitosan can also be easily modified chemically due to the presence of reactive functional hydroxide and amine groups. Folic acid is commonly engaged as a ligand, for targeting cancer cells, as its receptor, that transports folic acid into the cells through endocytosis and is over-expressed on the surface of several human epithelial cancer cells. Integrating folic acid into chitosan-based drug delivery inventions directs the systems with a well-organized targeting ability. The present review outlines several illustrations of this versatile system based on folate decorated chitosan, which have shown potential as auspicious delivery systems published over the past few years. In addition, it is probable to formulate chitosan nanocarriers that exhibit manifold usage beyond targeted delivery, such as nanotheranostics and cancer stem cell therapy.

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Section: Mitomycin Cmentioning

confidence: 94%

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

et al. 2017

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“…MTX + MMC codelivery using chitosan nanoparticles showed synergistic killing efficacy when tested against monodelivery of MTX and MMC [ 114 ]. In another study, Lin et al co-delivered MMC with 10-hydroxycamptothecin (HCPT) using folate functionalized soybean phosphatidylcholine micellar nanoformulation to test the therapeutic efficacy in HeLa Cells [ 115 ]. Direct cellular targeting of MMC and HCPT using micellar nanoparticles not only enhanced cellular uptake in in vitro and in vivo but also showed significant reduction in tumor burden compared to free drugs.…”

Section: Cellular Level Targetingmentioning

confidence: 99%

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

et al. 2017

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Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration. Nanomedicine can provide a more effective approach to targeting cancer by focusing on the vascular, tissue, and cellular characteristics that are unique to solid tumors. Targeted methods of treatment using nanoparticles can decrease the likelihood of resistant clonal populations of cancerous cells. Dual encapsulation of chemotherapeutic drug allows simultaneous targeting of more than one characteristic of the tumor. Several first-generation, non-targeted nanomedicines have received clinical approval starting with Doxil® in 1995. However, more than two decades later, second-generation or targeted nanomedicines have yet to be approved for treatment despite promising results in pre-clinical studies. This review highlights recent studies using targeted nanoparticles for cancer treatment focusing on approaches that target either the tumor vasculature (referred to as ‘vascular targeting’), the tumor microenvironment (‘tissue targeting’) or the individual cancer cells (‘cellular targeting’). Recent studies combining these different targeting methods are also discussed in this review. Finally, this review summarizes some of the reasons for the lack of clinical success in the field of targeted nanomedicines.

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“…The delivery of MMC through nanodrug delivery systems (including nanoparticles, polymer micelles, liposomes, and dendrimers, etc.) can significantly improve its targeting, change the biological distribution of the drugs, reduce the distribution of the drugs in normal tissues, and also increase the accumulation and retention time of drugs in tumor sites [9][10][11][12][13]. Because of the water-soluble characteristics of MMC, most MMC is first modified into prodrugs or lipid complexes, and then loaded with liposomes or encapsulated with nanoparticles (NPs) by the double emulsion solvent diffusion technique, or others [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…can significantly improve its targeting, change the biological distribution of the drugs, reduce the distribution of the drugs in normal tissues, and also increase the accumulation and retention time of drugs in tumor sites [9][10][11][12][13]. Because of the water-soluble characteristics of MMC, most MMC is first modified into prodrugs or lipid complexes, and then loaded with liposomes or encapsulated with nanoparticles (NPs) by the double emulsion solvent diffusion technique, or others [13][14][15][16][17]. However, most of the drug delivery methods of MMC reported in the literature have a low encapsulation efficiency, and it is difficult to maintain the stability of the drug in the carrier [16,17].…”

Section: Introductionmentioning

confidence: 99%

Development of Mitomycin C-Loaded Nanoparticles Prepared Using the Micellar Assembly Driven by the Combined Effect of Hydrogen Bonding and π–π Stacking and Its Therapeutic Application in Bladder Cancer

Liu

Zhang

et al. 2021

Pharmaceutics

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Micelle is mainly used for drug delivery and is prepared from amphiphilic block copolymers. It can be formed into an obvious core-shell structure that can incorporate liposoluble drugs. However, micelles are not suitable for the encapsulation of water-soluble drugs, and it is also difficult to maintain stability in the systemic circulation. To solve these problems, a type of polymer material, Fmoc-Lys-PEG and Fmoc-Lys-PEG-RGD, was designed and synthesized. These copolymers could self-assemble into micelles driven by π–π stacking and the hydrophobic interaction of 9-fluorenylmethoxycarbony (Fmoc) and, at the same time, form a framework for a hydrogen-bonding environment in the core. Mitomycin C (MMC), as a water-soluble drug, can be encapsulated into micelles by hydrogen-bonding interactions. The interaction force between MMC and the polymers was analyzed by molecular docking simulation and Fourier transform infrared (FTIR). It was concluded that the optimal binding conformation can be obtained, and that the main force between the MMC and polymers is hydrogen bonding. Different types of MMC nanoparticles (NPs) were prepared and the physicochemical properties of them were systematically evaluated. The pharmacodynamics of the MMC NPs in vitro and in vivo were also studied. The results show that MMC NPs had a high uptake efficiency, could promote cell apoptosis, and had a strong inhibitory effect on cell proliferation. More importantly, the as-prepared NPs could effectively induce tumor cell apoptosis and inhibit tumor growth and metastasis in vivo.

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Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy

Abstract: Polymer–lipid hybrid micelles co-delivered hydrophilic mitomycin C and hydrophobic 10-hydroxycamptothecin showed improved cellular uptake and cytotoxicity in vitro and enhanced tumor accumulation and antitumor activity in vivo.

Cited by 11 publications

References 49 publications

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

Development of Mitomycin C-Loaded Nanoparticles Prepared Using the Micellar Assembly Driven by the Combined Effect of Hydrogen Bonding and π–π Stacking and Its Therapeutic Application in Bladder Cancer

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