2006
DOI: 10.1590/s0100-879x2006000800002
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Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin

Abstract: Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues. Ghrelin is a novel acylated peptide which is produced mainly by the stomach. It is also synthesized in the hypothalamus and is present in several other tissues. This endogenous growth hormone secretagogue was discovered by reverse pharmacology when a group of synthetic growth hormone-r… Show more

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Cited by 15 publications
(10 citation statements)
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References 57 publications
(117 reference statements)
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“…While GHRH has not been measured in weaver mice, our results do not support the involvement of ghrelin, which stimulates GHRH secretion and amplifies GHRH's effects on the somatotroph [41]. This is deduced from the fact that weaver mice have normal food intake, which is also known to be regulated by ghrelin [41]. On the other hand, somatostatin mRNA levels are 20-87% higher in the weaver mouse hypothalamus as demonstrated by in situ hybridization [42].…”
Section: Discussioncontrasting
confidence: 77%
See 1 more Smart Citation
“…While GHRH has not been measured in weaver mice, our results do not support the involvement of ghrelin, which stimulates GHRH secretion and amplifies GHRH's effects on the somatotroph [41]. This is deduced from the fact that weaver mice have normal food intake, which is also known to be regulated by ghrelin [41]. On the other hand, somatostatin mRNA levels are 20-87% higher in the weaver mouse hypothalamus as demonstrated by in situ hybridization [42].…”
Section: Discussioncontrasting
confidence: 77%
“…Since homozygous weaver mice are reported to have normal pituitary GH mRNA levels [21], the cause of low GH circulating levels is likely related to the regulation of its release, which is under the control of a complex neuroendocrine network comprising hypothalamic GH releasing hormone, somatostatin, and ghrelin [3]. While GHRH has not been measured in weaver mice, our results do not support the involvement of ghrelin, which stimulates GHRH secretion and amplifies GHRH's effects on the somatotroph [41]. This is deduced from the fact that weaver mice have normal food intake, which is also known to be regulated by ghrelin [41].…”
Section: Discussioncontrasting
confidence: 69%
“…The most important synthetic chemical compounds stimulating the GH secretion are apomorphine (APO), propranolol, clonidine and synthetic growth hormone releasing peptide (GHRP), e.g. GHRP-6 and hexarelin (Low, 1991;Scacchi et al, 1999;Lengyel, 2006). The GH level also increases under the influence of glucogenic amino acids (arginine, glycine, glutamine), L-Doop, niacin, opioid peptides, galanin, vitamin A, or glucagon (Morita et al, 1989;Johnson et al, 1993;Zdrojewicz et al, 2000;Gómez et al, 2002;Arwert et al, 2003;Ginalska-Malinowska, Malinowska, 2009;Skottner, 2012;Vught et al, 2012).…”
Section: Regulation Of Secretionmentioning
confidence: 99%
“…A insulina suprime a secreção do GH e também diminui a expressão do gene, da mesma forma que a somatostatina. Já a ghrelina estimula a secreção do GH por uma via diferente do GHRH (14,16).…”
Section: Ensaios Para Medida Do Gh Na Acromegaliaunclassified