2007
DOI: 10.1007/s12020-007-9003-4
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Role of the GH/IGF-I axis in the growth retardation of weaver mice

Abstract: IGF-I is a well-established anabolic growth factor essential for growth and development. Although the role of the GH/IGF-I axis is established for normal postnatal growth, its functional state in neurodegenerative diseases is not fully characterized. The weaver mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides an opportunity to investigate the function of IGF-I in postnatal growth following neurodegeneration. Previously, we reported that weaver mice are growth retarde… Show more

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Cited by 2 publications
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“…Heterozygous weaver mice have a decreased number of surviving granule cells and suffer sporadically from tonic-clonic seizures [Patil et al, 1995]. Also, homozygous weaver mice have decreased levels of circulating IGF1 and responded to GH-treatment [Yao et al, 2007]. The postnatal growth retardation in our patients might be partially explained by a deficient GH/IGF1 axis, as seen in mutant weaver mice.…”
Section: Discussionmentioning
confidence: 73%
“…Heterozygous weaver mice have a decreased number of surviving granule cells and suffer sporadically from tonic-clonic seizures [Patil et al, 1995]. Also, homozygous weaver mice have decreased levels of circulating IGF1 and responded to GH-treatment [Yao et al, 2007]. The postnatal growth retardation in our patients might be partially explained by a deficient GH/IGF1 axis, as seen in mutant weaver mice.…”
Section: Discussionmentioning
confidence: 73%
“…Regardless, malnutrition due to lower food intake is unlikely the cause of low IGF-I circulating levels, because homozygous weaver mice consumed the same amount of food as their wild-type littermates (Yao et al, 2007). On the other hand, decreased circulating IGF-I in weaver mice likely results from their lower circulating GH levels (50% lower) (Yao et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
“…Regardless, malnutrition due to lower food intake is unlikely the cause of low IGF-I circulating levels, because homozygous weaver mice consumed the same amount of food as their wild-type littermates (Yao et al, 2007). On the other hand, decreased circulating IGF-I in weaver mice likely results from their lower circulating GH levels (50% lower) (Yao et al, 2007). Since GH also has positive effects on bone mass and BMD (Johansson et al, 1992), it is likely that the decrease in bone growth results from a combined deficiency of the GH/IGF-I axis.…”
Section: Discussionmentioning
confidence: 99%
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