“…Microvascular dysfunction contributes to inflammation in visceral fat, which may explain the associated elevation in cardiovascular risk in subjects with excess visceral adiposity 31 . Microcirculatory dysfunction contributes etiologically or has a primary association with a myriad of diseases including obstructive sleep apnea 32 , hypertrophic cardiomyopathy 10 , stress-related cardiomyopathy 33 , congestive heart failure with reduced ejection fraction 34 , idiopathic cardiomyopathy 35 , heart failure with preserved ejection fraction 36, 37 , inflammatory bowel disease 38, 39 , schizophrenia 40 , amyloidosis 41 , tobacco use 42 , aging 43 , systemic lupus erythematosus 44 , and even a sedentary life style 45 . Abnormalities in the microcirculation are responsible for no-reflow phenomenon (reviewed by Feher et al 46 ), damage from cardioplegic arrest 47 , coronary microvascular spasm 48 , cerebral vasospasm following subarachnoid hemorrhage 49 , and angiogenesis 50, 51 , including tumor angiogenesis 52 .…”