Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing

Cavaleiro, Eliana Marisa dos Santos; Duarte, Ana Sofia; Esteves, Ana Cristina; Correia, António; WhitcombePhD, Michael J.; Piletska, Elena; Piletsky, Sergey A.; Chianella, Iva

doi:10.1002/mabi.201400447

Cited by 27 publications

(35 citation statements)

References 48 publications

(72 reference statements)

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“…Very few polymers have been reported that inhibit QS and biofilm formation at the same time . These polymers can only inhibit biofilm formation at the initial stages.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and anti‐quorum‐sensing properties and paint film usage of novel diazaborine‐based copolymers

Koçak¹,

Çiçek²,

Ceylan

et al. 2018

J of Applied Polymer Sci

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To meet high hygiene requirements, intensive studies are being carried out on antimicrobial materials. This study reports the synthesis of 3‐((1‐hydroxybenzo[d][1,2,3]diazaborinin‐2(1H)‐yl)sulfonyl)propyl methacrylate (DAZBMA) and its polymer, which is antimicrobial [tested with Staphylococcus aureus (ATCC 25923 and MU 40) and Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10239] on solid surfaces. Antibiofilm capability was tested against MU 40. Although DAZBMA and its polymer show a high quorum‐sensing inhibition property (tested with Chromobacterium violaceum CV 026 and CV 12472 and P. aeruginosa PA01), the lesser antibacterial activity of the polymer was improved by copolymerizing DAZBMA with quaternized 2‐dimethylaminoethyl methacrylate. The paint films containing the prepared copolymer are highly active against all tested bacteria and show an antibiofilm effect against hospital‐acquired multiple‐antibiotic‐resistant MU 40. The novel copolymer can be used in water‐soluble paints to reduce its biofilm production and pathogenicity, especially for paints used in hospitals. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46907.

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“…Very few polymers have been reported that inhibit QS and biofilm formation at the same time . These polymers can only inhibit biofilm formation at the initial stages.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and anti‐quorum‐sensing properties and paint film usage of novel diazaborine‐based copolymers

Koçak¹,

Çiçek²,

Ceylan

et al. 2018

J of Applied Polymer Sci

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“…56,57 In contrast, CHX does not affect significantly the viability of murine macrophages, but may have an immunosuppressive effect on exposed macrophages. 58 A recent study demonstrated that cytotoxicity of CHX might be reduced using modified nonequilibrium plasma. Considering these data, plasma-based modification was proposed as a safe option for root canal treatment.…”

mentioning

confidence: 99%

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Tokajuk

Niemirowicz

Deptuła

et al. 2017

IJN

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Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX). In the presence of human saliva, MNPs@CHX displayed significantly greater bactericidal and fungicidal activity against planktonic and biofilm-forming microorganisms than free CHX. In addition, CHX attached to MNPs has an increased ability to restrict the growth of mixed-species biofilms compared to free CHX. The observed depolarization of mitochondria in fungal cells treated with MNP@CHX suggests that induction of oxidative stress and oxidation of fungal structures may be a part of the mechanism responsible for pathogen killing. Nanoparticles functionalized by CHX did not affect host cell proliferation or their ability to release the proinflammatory cytokine, IL-8. The use of MNPs as a carrier of CHX has great potential for the development of antiseptic nanosystems.

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“…Cavaleiro et al suggest that the inhibitory effects were caused by attenuation of quorum sensing through sequestration of signal molecules [46]. Quorum sensing (QS) is a fundamental mechanism responsible for microbial communication and several pathogenic behaviors including virulence factors secretion and biofilm formation.…”

Section: Biological Propertiesmentioning

confidence: 99%

Assessment of aliphatic poly(ester-carbonate-urea-urethane)s potential as materials for biomedical application

et al. 2017

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Selected mechanical and biological properties of biodegradable elastomeric poly(ester-carbonate-urea-urethane)s (PECUUs) point towards their potential to be applied as scaffolds in tissue engineering. Here we explore their medical applicability taking into account their hemocompatibility and cytotoxicity. The influence of the ester monomer (derivatives of adipic and succinic acids), as well as diisocyanate type (IPDI and HDI) on the investigated PECUUs properties is presented. The presence of aliphatic diisocyanates, cyclic IPDI or linear HDI, governs the adhesion of Candida cells to these polymers offering the possibility to control the biofilm formation on their surface. In comparison to the linear form, cyclic diisocyanates with pentamethylene succinate or adipate fragments had two to three times lower biofilm mass formation on their surface. Reduced hemoglobin release from red blood cells observed during incubation of tested polymers with human erythrocytes suspension indicates their potential biocompatibility with human tissues. PECUUs were also able to support the growth of human keratinocytes HaCaT on their surface when coated with collagen. In effect, IPDI derivatives might possess a high potential for use in biomedical applications.

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Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing

Cited by 27 publications

References 48 publications

Antimicrobial and anti‐quorum‐sensing properties and paint film usage of novel diazaborine‐based copolymers

Antimicrobial and anti‐quorum‐sensing properties and paint film usage of novel diazaborine‐based copolymers

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Assessment of aliphatic poly(ester-carbonate-urea-urethane)s potential as materials for biomedical application

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