Assessment of aliphatic poly(ester-carbonate-urea-urethane)s potential as materials for biomedical application

Abstract

Selected mechanical and biological properties of biodegradable elastomeric poly(ester-carbonate-urea-urethane)s (PECUUs) point towards their potential to be applied as scaffolds in tissue engineering. Here we explore their medical applicability taking into account their hemocompatibility and cytotoxicity. The influence of the ester monomer (derivatives of adipic and succinic acids), as well as diisocyanate type (IPDI and HDI) on the investigated PECUUs properties is presented. The presence of aliphatic diisocyanates, cyclic IPDI or linear HDI, governs the adhesion of Candida cells to these polymers offering the possibility to control the biofilm formation on their surface. In comparison to the linear form, cyclic diisocyanates with pentamethylene succinate or adipate fragments had two to three times lower biofilm mass formation on their surface. Reduced hemoglobin release from red blood cells observed during incubation of tested polymers with human erythrocytes suspension indicates their potential biocompatibility with human tissues. PECUUs were also able to support the growth of human keratinocytes HaCaT on their surface when coated with collagen. In effect, IPDI derivatives might possess a high potential for use in biomedical applications.

Designing Smart Biomaterials for Tissue Engineering

“…Although proteins are highly biocompatible, their very fast degradation and low mechanical strength result in a lack of structural support during tissue development. Polymeric biomaterials are also developed by polymerizing one or more monomers either by homopolymer reaction or copolymer reaction to form non-biodegradable [ 6 , 7 ] and biodegradable materials [ 8 , 9 ]. The structure, molecular chain length, and stereochemistry can be tailored by varying chemical and physical parameters during synthesis.…”

The Influence of Mucin-Based Artificial Saliva on Properties of Polycaprolactone and Polylactide

“…The main reason for this situation is the biostability requirement of long-term implants and the need for revision surgery. The most important group of this type of applications are polymers [1,2,3,4]. Depending on the intended use, polymeric biomaterials may require a specific stability/degradation time.…”

Polymeric Materials Based on Carbon Dioxide: A Brief Review of Studies Carried Out at the Faculty of Chemistry, Warsaw University of Technology

“…In another study, we have shown that PECUUs based on adipic acid derivatives are characterized by a lower glass transition temperature, higher elongation at break, and higher tensile strength compared to PECUUs containing succinate groups. Analysis of water sorption and changes in the pH of the solution after immersion tests indicates that the samples most prone to water penetration and hydrolysis were those obtained from IPDI [37]. Furthermore, the resistance of these PECUUs to biological colonization, i.e., against Candida species, as well as their hemocompatibility and lack of cytotoxicity were examined.…”