Novel Laser-Activated Solder for Sealing Corneal Wounds

Noguera, Guillermo; Lee, Woo Seok; Castro-Combs, Juan; Chuck, Roy S.; Soltz, Barbara A.; Soltz, Robert; Behrens, Ashley

doi:10.1167/iovs.06-0488

Cited by 18 publications

(19 citation statements)

References 47 publications

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“…Other experimental adhesives have been synthesized [13][14][15][16][17][18] ; however, only 2 of them 15,16 could seal incisions with pressures well above 110 mm Hg. One adhesive was also polysaccharide-based, crosslinked with a PEG amine molecule, but the sugar was dextran aldehyde.…”

Section: Discussionmentioning

confidence: 99%

“…The adhesives are classified as biological, 13 synthetic, 14 or a combination of the two [15][16][17] ; while some useful techniques to seal the incision include the use of soldering materials 18 and tissue welding. 19 We previously developed an ocular adhesive based on chondroitin sulfate (CS) 17 but modified the chemistry in the current study to enhance biocompatibility.…”

mentioning

confidence: 99%

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Synthesis and characterization of a chondroitin sulfate-polyethylene glycol corneal adhesive

Strehin

Ambrose

Schein

et al. 2009

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Synthesis and characterization of a chondroitin sulfate-polyethylene glycol corneal adhesive

Strehin

Ambrose

Schein

et al. 2009

Journal of Cataract and Refractive Surgery

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“…Solders can direct thermal absorption not only at the edges of a wound, but can also be applied beyond the edges to form adherent sleeves, which can significantly enhance the overall bonding strength [194]. The solder can also be used as an effective sealant or hemostatic agent.…”

Section: Laser Solderingmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…We used an albumin solution for soldering because it is readily available, whereas collagen solder, though found to be effective compared to sutures [22], is difficult to prepare.…”

Section: Introductionmentioning

confidence: 99%

CO<sub>2</sub> Laser Welding of Corneal Cuts with Albumin Solder Using Radiometric Temperature Control

Strassmann

Livny²,

Loya³

et al. 2013

Ophthalmic Res

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Purpose: To examine the efficacy and reproducibility of CO₂ laser soldering of corneal cuts using real-time infrared fiber-optic radiometric control of tissue temperature in bovine eyes (in vitro) and to evaluate the duration of this procedure in rabbit eyes (in vivo). Methods: In vitro experiment: a 6-mm central perforating cut was induced in 40 fresh bovine eyes and sealed with a CO₂ laser, with or without albumin soldering, following placement of a single approximating nylon suture. A fiber-optic radiometric temperature control system for the CO₂ laser was used. Leaking pressure and histological findings were analyzed and compared between groups. In vivo experiment: following creation of a central perforation, 6 rabbit eyes were treated with a CO₂ laser with albumin solder and 6 rabbit eyes were treated with 10-0 nylon sutures. The amount of time needed for completion of the procedures was compared. Results: In vitro experiment: effective sealing was achieved by CO₂ laser soldering. Mean (± SD) leaking pressure was 109 ± 30 mm Hg in the bovine corneas treated by the laser with albumin solder compared to 51 ± 7 mm Hg in the sutured control eyes (n = 10 each; p < 0.001). Mean leaking pressures were much lower in the corneal cuts sealed only with the laser without albumin solder (48 ± 12 mm Hg) and in the cuts sealed only with albumin without laser welding (6.3 ± 4 mm Hg) than in the cuts treated with laser welding and albumin solder. In vivo experiment: mean surgical time was 140 ± 17 s in the laser-treated rabbits compared to 330 ± 30 s in the sutured controls (n = 6; p < 0.001). A histopathological study of the rabbit corneas 1 day after laser soldering revealed sealed corneal edges with a small gap bridged by coagulated albumin. The inflammatory reaction was minimal in contrast to the sutured controls. No thermal damage was detected at the wound edges. Conclusions: CO₂ laser soldering combined with the fiber-optic radiometer is an effective, reliable, and rapid tool for the closure of corneal wounds, and holds advantages over conventional suturing in terms of leaking pressure and surgical time.

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Novel Laser-Activated Solder for Sealing Corneal Wounds

Abstract: The tested laser-activated solder was as effective as sutures when used as a patch and superior to sutures for clear corneal incisions in this animal ex vivo model.

Cited by 18 publications

References 47 publications

Synthesis and characterization of a chondroitin sulfate-polyethylene glycol corneal adhesive

Synthesis and characterization of a chondroitin sulfate-polyethylene glycol corneal adhesive

Tissue adhesives in ocular surgery

CO<sub>2</sub> Laser Welding of Corneal Cuts with Albumin Solder Using Radiometric Temperature Control

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