Novel insights in SHBG regulation and clinical implications

Simó, Rafael; Sáez-López, Cristina; Barbosa-Desongles, Anna; Hernández, Cristina; Selva, David M.

doi:10.1016/j.tem.2015.05.001

Cited by 230 publications

(184 citation statements)

References 82 publications

Supporting

Mentioning

175

Contrasting

Order By: Relevance

“…Hyperinsulinism also indirectly produces changes in sex hormone-binding globulin (SHBG) levels, including increases in the levels of oestrogen [69]. High BMI (and hyperadiponectinemia) and non-alcoholic fatty liver may also increase circulating SHBG [70,71]. In our systematic review, only Dossus et al [36] reported the univariable association between SHBG levels and EC and there were no studies reporting fatty liver characteristics.…”

Section: Discussionmentioning

confidence: 84%

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Hernandez

Pasupuleti

Benítes-Zapata

et al. 2015

European Journal of Cancer

127

View full text Add to dashboard Cite

Aim: It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods: We searched PubMed-Medline, Embase, Scopus, and Web of Science for articles published from database inception through 30th September 2014. We included all observational studies evaluating components defining insulin resistance in women with and without EC. Quality of the included studies was assessed by NewcastleeOttawa scale. Randomeffects models and inverse variance method were used to meta-analyze the association between insulin resistance components and EC. Results: Twenty-five studies satisfied our inclusion criteria. Fasting insulin levels (13 studies, n Z 4088) were higher in women with EC (mean difference [MD] 33.94 pmol/L, 95% confidence interval [CI] 15.04e52.85, p Z 0.0004). No differences were seen in postmenopausal versus pre-and postmenopausal subgroup analysis. Similarly, non-fasting/fasting C-peptide levels (five studies, n Z 1938) were also higher in women with EC (MD 0.14 nmol/L, 95% * Corresponding author: Research Center, School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Building F, Campus Villa, Avenida Alameda de San Marcos Cuadra 2 s/n, Chorrillos, Lima 9, Peru. Tel.: þ51 1 3133333x2730.E-mail addresses: adrianhernandezdiaz@gmail.com (A.V. Hernandez), lepiscean@gmail.com (V. Pasupuleti), vbeniteszapata@gmail. com (V.A. Benites-Zapata), tpriyaleela@gmail.com (P. Thota), abhishekdp@gmail.com (A. Deshpande), faustino.perez@unizar.es (F.R. Perez-Lopez).1 Contributed equally to the study.

show abstract

Section: Discussionmentioning

confidence: 84%

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Hernandez

Pasupuleti

Benítes-Zapata

et al. 2015

European Journal of Cancer

127

View full text Add to dashboard Cite

show abstract

“…The reduced secretion of SHBG in patients with PCOS is believed to result from the combined inhibitory influence of portal insulin levels (55), proinflammatory mediators mostly secreted by liver adipose tissue (56), and excessive circulating androgens (57) in association with insulin resistance, visceral adiposity, and hyperandrogenism. However, the lack of reduced SHBG concentrations in women with type 1 diabetes and PCOS may suggest that the major pathogenetic mechanism is related to the subcutaneous route of administration of insulin (58).…”

Section: Discussionmentioning

confidence: 99%

Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Escobar-Morreale

Roldán-Martín

2016

Diabetes Care

View full text Add to dashboard Cite

A few small studies have reported increased prevalences of polycystic ovary syndrome (PCOS) and symptoms of androgen excess in women with type 1 diabetes. PURPOSEWe performed a systematic review and meta-analysis of studies evaluating androgen excess symptoms and PCOS in women with type 1 diabetes. DATA SOURCESThe Entrez-PubMed and Scopus electronic databases were used. STUDY SELECTIONWe selected studies addressing androgen excess signs, symptoms, and disorders in girls, adolescents, and adult women with type 1 diabetes. DATA EXTRACTIONThe main outcome measures were prevalences of PCOS, hyperandrogenemia, hirsutism, menstrual dysfunction, and polycystic ovarian morphology (PCOM). DATA SYNTHESISNine primary studies involving 475 adolescent or adult women with type 1 diabetes were included. The prevalences of PCOS and associated traits in women with type 1 diabetes were 24% (95% CI 15-34) for PCOS, 25% (95% CI 17-33) for hyperandrogenemia, 25% (95% CI 16-36) for hirsutism, 24% (95% CI 17-32) for menstrual dysfunction, and 33% (95% CI 24-44) for PCOM. These figures are considerably higher than those reported earlier in the general population without diabetes. LIMITATIONSThe data collected in the original studies were heterogeneous in age, race, ethnicity, and criteria used for the diagnosis of PCOS; yet, we used a quality-effects model in the meta-analyses to overcome this limitation. CONCLUSIONSPCOS and its related traits are frequent findings in women with type 1 diabetes. PCOS may contribute to the subfertility of these women by a mechanism that does not directly depend on glycemic/metabolic control among other negative consequences for their health. Hence, screening for PCOS and androgen excess should be included in current guidelines for the management of type 1 diabetes in women.

show abstract

“…This confirms the results from previous studies, showing a 5-to 10-fold increase during pregnancy (13,14) and a 2-to 4-fold increase in women using OAC (15,16), which is due to estrogens stimulating the liver to produce SHBG. Increased serum SHBG concentrations are also seen in samples from patients with anorexia nervosa, hyperthyroidism, and Cushing disease (17). Patients with obesity, polycystic ovary syndrome, and metabolic syndrome all have lower SHBG concentration, which is probably due to hepatic fat content inhibiting SHBG production (17).…”

mentioning

confidence: 99%

“…Increased serum SHBG concentrations are also seen in samples from patients with anorexia nervosa, hyperthyroidism, and Cushing disease (17). Patients with obesity, polycystic ovary syndrome, and metabolic syndrome all have lower SHBG concentration, which is probably due to hepatic fat content inhibiting SHBG production (17).…”

mentioning

confidence: 99%

Inaccurate First-Generation Testosterone Assays Are Influenced by Sex Hormone–Binding Globulin Concentrations

Heijboer

Savelkoul

Kruit

et al. 2016

The Journal of Applied Laboratory Medicine

View full text Add to dashboard Cite

Background: The quality of testosterone assays has been a matter of debate for several years. Known limitations of testosterone immunoassays are the cross-reactivity with other steroids and a high variation in the low concentration range. We hypothesized that one of the additional limitations of testosterone immunoassays is an ineffective displacement of testosterone from its binding protein. Methods:Thirty samples from women not using oral contraceptives (OAC), 30 samples from women using OAC, and 30 samples from pregnant women were used to measure testosterone by an isotope dilution (ID)-LC-MS/MS method and by 6 commercially available testosterone immunoassays (UniCel

show abstract

Novel insights in SHBG regulation and clinical implications

Cited by 230 publications

References 82 publications

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Inaccurate First-Generation Testosterone Assays Are Influenced by Sex Hormone–Binding Globulin Concentrations

Contact Info

Product

Resources

About