Novel Influenza H1N1 in Pregnancy: A Report of Two Cases

Fridman, Dmitry; Kuzbari, Oumar; Minkoff, Howard

doi:10.1155/2009/514353

Cited by 7 publications

(2 citation statements)

References 5 publications

(8 reference statements)

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“…Importantly, as Rasmussen et al noted, the different degrees of influenza illness severity in the mother and the difficulty in separating the effects of the infection itself from those of the medications used to treat the infection will make research and interpretation of research findings difficult [ 75 ]. Fridman et al documented that chorioamnionitis was suspected in 1 of 2 pregnant women infected with A(H1N1)pdm09 virus at 37 weeks' gestation, but they did not clarify the infectious agents for chorioamnionitis [ 48 ]. Yet, clinical research efforts are greatly needed.…”

Section: Lessons From Pandemic H1n1 2009 In Pregnancymentioning

confidence: 99%

Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

Uchide

Ohyama

Bessho³

et al. 2012

Mediators of Inflammation

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Pregnant women are at an increased risk of influenza-associated adverse outcomes, such as premature delivery, based on data from the latest pandemic with a novel influenza A (H1N1) virus in 2009-2010. It has been suggested that the transplacental transmission of influenza viruses is rarely detected in humans. A series of our study has demonstrated that influenza virus infection induced apoptosis in primary cultured human fetal membrane chorion cells, from which a factor with monocyte differentiation-inducing (MDI) activity was secreted. Proinflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β, were identified as a member of the MDI factor. Influenza virus infection induced the mRNA expression of not only the proinflammatory cytokines but also chemoattractive cytokines, such as monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1β, IL-8, growth-regulated oncogene (GRO)-α, GRO-β, epithelial cell-derived neutrophil-activating protein (ENA)-78, and interferon inducible protein (IP)-10 in cultured chorion cells. These cytokines are postulated to associate with human parturition. This paper, therefore, reviews (1) lessons from pandemic H1N1 2009 in pregnancy, (2) production of proinflammatory and chemoattractive cytokines by human fetal membranes and their functions in gestational tissues, and (3) possible roles of cytokines produced by human fetal membranes in the pathology of adverse pregnancy outcomes associated with influenza virus infection.

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Section: Lessons From Pandemic H1n1 2009 In Pregnancymentioning

confidence: 99%

Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

Uchide

Ohyama

Bessho³

et al. 2012

Mediators of Inflammation

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“…Acute H 1 N 1 infections in pregnancy have been reported in the current pandemic leading to severe morbidity, as seen in our two patients, and mortality [14,15]. The fact that this influenza A (H 1 N 1 ) can develop in healthy patients and evolve in few hours to a severe ARDS with a refractory hypoxemia needing recourse to ECMO in 5% to 20% of patients is novel [16,17].…”

Section: Discussionmentioning

confidence: 81%

Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literature

2011

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IntroductionMyocarditis is rarely reported as an extra-pulmonary manifestation of influenza while pregnancy is a rare cause of cardiomyopathy. Pregnancy was identified as a major risk factor for increased mortality and morbidity due to H1N1 influenza in the pandemic of 2009 to 2010. However, to the best of our knowledge there are no previous reports in the literature linking H1N1 with myocarditis in pregnancy.Case presentationWe report the cases of two pregnant Caucasian women (aged 29 and 30), with no pre-existing illness, presenting with respiratory manifestations of H1N1 influenza virus infection in their third trimester. Both women developed evidence of myocarditis. One woman developed acute respiratory distress syndrome, almost reaching the point of requiring extra-corporeal membrane oxygenation, and subsequently developed persistent cardiomyopathy; the other recovered without any long-term consequence.ConclusionsWhile it is not possible to ascertain retrospectively if myocarditis was caused by either infection with H1N1 virus or as a result of pregnancy (in the absence of endomyocardial biopsies), the significant association with myocardial involvement in both women demonstrates the increased risk of exposure to H1N1 influenza virus in pregnant women. This highlights the need for health care providers to increase awareness amongst caregivers to target this 'at risk' group aggressively with vaccination and prompt treatment.

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2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature

Mosby

Rasmussen

Jamieson

2011

American Journal of Obstetrics and Gynecology

311

231

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Novel Influenza H1N1 in Pregnancy: A Report of Two Cases

Cited by 7 publications

References 5 publications

Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literature

2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature

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