Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literature

Chan, Karen M. K.; Meek, David W.; Chakravorty, Indranil

doi:10.1186/1752-1947-5-314

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…The number of female patients was larger than the number of male patients, although general acute myocarditis is more common in males [69, 70]. Further, although pregnancy is reported to be a risk factor for deterioration of pandemic influenza infection, only one of the women in this paper was pregnant [38]. The mean interval from influenza onset to cardiac involvement was 5.4 days.…”

Section: Myocarditis Associated With Influenza H1n1pdm2009 In Thementioning

confidence: 96%

Myocarditis Associated with Influenza A H1N1pdm2009

Ukimura

Satomi

Ooi

et al. 2012

Influenza Research and Treatment

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Acute myocarditis is a well-known complication of influenza infection. The frequency of myocardial involvement in influenza infection varies widely, with the clinical severity ranging from asymptomatic to fulminant varieties. The worst cases can result in death due to impaired cardiac function, although such fulminant myocarditis associated with influenza infection is rare, as shown by previous papers. Following the 2009 influenza pandemic, we reported on the clinical features of a cohort of 15 patients in Japan with H1N1pdm2009 myocarditis. In our subsequent survey of the literature for case reports or series of patients with myocarditis associated with H1N1pdm2009, we identified 58 detailed cases. We discuss here the high prevalence of fulminant myocarditis (36/58, 62%) among patients reported to have myocarditis associated with H1N1pdm2009. Mechanical circulatory support was required in 17 of the patients with fulminant myocarditis, 13 of whom recovered. We stress the need for increased awareness of influenza-associated myocarditis; such knowledge will facilitate earlier diagnosis and treatment of this fatal complication during future influenza pandemics.

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Section: Myocarditis Associated With Influenza H1n1pdm2009 In Thementioning

confidence: 96%

Myocarditis Associated with Influenza A H1N1pdm2009

Ukimura

Satomi

Ooi

et al. 2012

Influenza Research and Treatment

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“…Extra-respiratory tract complications are occasionally described in pregnant women. These include the development of myocarditis after infection with A(H1N1)pdm09 [28,29], and the development of an encephalopathy associated with a seasonal H3N2 IAV infection from which viral RNAwas detected in cerebrospinal fluids [30].…”

Section: Influenza a Virus Pathogenesis In Pregnant Womenmentioning

confidence: 99%

Influenza pathogenicity during pregnancy in women and animal models

et al. 2016

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Pregnant women are at the highest risk to develop severe and even fatal influenza. The high vulnerability of women against influenza A virus infections during pregnancy was repeatedly highlighted during influenza pandemics including the pandemic of this century. In 2009, mortality rates were particularly high among otherwise healthy pregnant women. However, our current understanding of the molecular mechanisms involved in severe disease development during pregnancy is still very limited. In this review, we summarize the knowledge on the clinical observations in influenza A virus-infected pregnant women. In addition, knowledge obtained from few existing experimental infections in pregnant animal models is discussed. Since clinical data do not provide in-depth information on the pathogenesis of severe influenza during pregnancy, adequate animal models are urgently required that mimic clinical findings. Studies in pregnant animal models will allow the dissection of involved molecular disease pathways that are key to improve patient management and care.

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“…There have been few reports on acute myocarditis during pregnancy, and no consensus exists on delivery strategies after 34 weeks of gestation. Some studies have described abortion [5], whereas some have also reported cases in which the mothers and their children were saved by cesarean section [6]. Both cases with abortion and successful saving of mother and child were reported.…”

Section: Discussionmentioning

confidence: 99%