Novel Implant Design Improves Implant Survival in Multirooted Extraction Sites: A Preclinical Pilot Study

Sivan-Gildor, Adi; Machtei, Eli E.; Gabay, Eran; Frankenthal, Shai; Levin, Liran; Suzuki, Marcelo; Coelho, Paulo G.; Zigdon‐Giladi, Hadar

doi:10.1902/jop.2014.140042

Cited by 8 publications

(6 citation statements)

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“…Notably, 3 to 4 implants can be anchored per quadrant [ 284 ] with human or human-like implants 4 mm in diameter and 11 mm in length [ 286 ]. As for the tibia, the oral model may be useful for histological analyses such as cytotoxicity and viability of new compositions [ 287 , 288 , 289 , 290 ] but also for assessments on 1:1 scale models of mechanical properties [ 47 , 268 , 291 ], stress distribution [ 287 , 288 ], and the effects of different implant and abutment shapes [ 264 , 284 , 292 , 293 , 294 , 295 ]. Thanks to pigs having similar bone properties to those of humans, resistance to insertion [ 273 ] or removal torque can be measured during [ 296 ] or after healing [ 268 ].…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

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Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.

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Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

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“…Furthermore, stress distribution on short implants is affected by the bone-to-implant contact ratio [ 24 ]. Consequently, several options to increase the implant surface of short implants are elaborated, which consecutively enhance the implant stability: thread number, thread shape, thread depth, implant diameter, implant design and surface topography [ 25 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Novel expandable short dental implants in situations with reduced vertical bone height—technical note and first results

et al. 2017

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PurposeShort implants often have the disadvantage of reduced primary stability. The present study was conducted to evaluate the feasibility and safety of a new expandable short dental implant system intended to increase primary stability.MethodsAs a “proof of concept”, a prospective clinical cohort study was designed to investigate intraoperative handling, primary and secondary implant stability (resonance frequency analysis), crestal bone changes, implant survival and implant success, of an innovative short expandable screw implant. From 2014 until 2015, 9 patients (7–9-mm vertical bone height) with 30 implants (length 5–7 mm, diameter 3.75–4.1 mm) were recruited consecutively.ResultsAll 30 implants in the 9 patients (age 44 to 80 years) could be inserted and expanded without intraoperative problems. Over the 3-year follow-up period, the implant success rate was 28/30 (93.3%). The mean implant stability quotients (ISQ) were as follows: primary stability, 69.7 ± 10.3 ISQ units, and secondary stability, 69.8 ± 10.2 ISQ units (p = 0.780), both without significant differences between the maxilla and mandible (p ≥ 0.780). The mean crestal bone changes after loading were (each measured from the baseline) as follows: in the first year, 1.0 ± 0.9 mm in the maxilla and 0.7 ± 0.4 mm in the mandible, and in the second year, 1.3 ± 0.8 mm and 1.0 ± 0.7 mm, respectively.ConclusionsCompared to other prospective studies, in this indication, the success rate is acceptable. Implant stability shows high initial and secondary stability values. The system might present an extension of functional rehabilitation to the group of elderly patients with limited vertical bone height. Further long-term investigations should directly compare this compressive implant with standard short implants.Electronic supplementary materialThe online version of this article (10.1186/s40729-017-0107-1) contains supplementary material, which is available to authorized users.

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“…12 In this context, recent studies have shown that in order to induce controlled compression forces in the cortical bone layer during implant insertion, a new hybrid auto-implant has been specifically designed for use in critical-quality bone, which combines the advantages of a conical implant with those of a cylindrical shape. 13 Considering the increase in the complexity of the cases in oral rehabilitations, modifications in the macro-geometry in implants should seek to favor their insertion, promoting the cut and bone compaction to increase their primary stability.…”

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confidence: 99%

“…Different implant designs were also tested by some authors in vivo and in vitro, 12,18,19 to increase the surface area of the implant with the bone tissue. Lundgren and colleagues, 18 and Sivan-Gildor and colleagues, 12 developed "hollow" implants in their inner portion and both concluded that the greater contact of the implant with the bone surface favored the success rate of these implants.…”

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confidence: 99%

“…Lundgren and colleagues, 18 and Sivan-Gildor and colleagues, 12 developed "hollow" implants in their inner portion and both concluded that the greater contact of the implant with the bone surface favored the success rate of these implants. Meirelles and colleagues, 19 performed a modification at the apex of the implant creating a "chamber", and demonstrated in histological sections, the bone formation in this space in the period of 1 month in rabbits.…”

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Evaluation of primary stability in modified implants: Analysis by resonance frequency and insertion torque

Sciasci

Casalle

Vaz

2018

Clin Implant Dent Rel Res

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Novel Implant Design Improves Implant Survival in Multirooted Extraction Sites: A Preclinical Pilot Study

Abstract: The novel design implants resulted in significantly greater survival rate in multirooted extraction sites. Further studies will be required to validate these findings.

Cited by 8 publications

References 21 publications

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Novel expandable short dental implants in situations with reduced vertical bone height—technical note and first results

Evaluation of primary stability in modified implants: Analysis by resonance frequency and insertion torque

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