Novel human Metapneumovirus with a 180-Nucleotide Duplication in the
            <i>G</i>
            Gene

Piñana, María; Vila, Juan J.; Gimferrer, Laura; Valls, María; Andrés, Cristina; Codina, María Gema; Ramón, Javier; Martín, Maria Carmen; Fuentes, Francisco; Saiz, Rosario; Alcubilla, Pilar; Rodrigo, Carlos; Pumarola, Tomás; Antón, Andrés

doi:10.2217/fmb-2016-0211

Cited by 23 publications

(33 citation statements)

References 16 publications

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“…Further detailed sequence analyses of HMPV strains have suggested two clades, A2a and A2b, in the A2 subgroup . Recently, unique A2b 180nt‐dup HMPV were detected in Japan and Spain . Our work has suggested that HMPV‐A2b 180nt‐dup emerged between 2011 and 2013 .…”

Section: Numbers Of Hmpv Strains Detected In Yokohama City Japan Betmentioning

confidence: 59%

“…In 2017, three novel HMPV A2b strains with 111nt‐dup in the G gene (A2b 111nt‐dup HMPV) were identified by the present team. Before 2016, no A2b 111nt‐dup HMPV strain had been detected (Table ). Relevant basic and clinical characteristics of the three individuals infected with A2b 111nt‐dup HMPV are summarized in Table .…”

Section: Numbers Of Hmpv Strains Detected In Yokohama City Japan Betmentioning

confidence: 99%

“…A2b 111nt-dup (this study) and A2b 180nt-dup HMPV strains (6) detected in Yokohama city are highlighted in blue and pink, respectively. A2b 180nt-dup HMPV strains detected in Spain (7) are highlighted in yellow. Fig.…”

Section: Acknowledgmentsmentioning

confidence: 99%

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A novel 111‐nucleotide duplication in the G gene of human metapneumovirus

Saikusa

Nao

Kawakami

et al. 2017

Microbiology and Immunology

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In 2017, novel human metapneumovirus (HMPV) A2b subgroup strains with a 111-nucleotide duplication in the G gene was detected by the present team. These strains were related to previously identified HMPV A2b strains with a 180-nucleotide duplication; however, they appeared to be different strains, produced by an independent duplication event. The recent evolution of HMPV suggests that careful monitoring of this virus is required.

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Section: Numbers Of Hmpv Strains Detected In Yokohama City Japan Betmentioning

confidence: 59%

Section: Numbers Of Hmpv Strains Detected In Yokohama City Japan Betmentioning

confidence: 99%

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A novel 111‐nucleotide duplication in the G gene of human metapneumovirus

Saikusa

Nao

Kawakami

et al. 2017

Microbiology and Immunology

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“…Detailed phylogenetic analysis of HMPV strains shows two distinct lineages, A2a and A2b, in the subgroup A2 (7). Recently, unique variant HMPV strains possessing a 180-or 111-nucleotide duplication (nt-dup) in the G gene were detected in Japan, Spain, Vietnam, and China (GeneBank accession number MF462419.1) (8)(9)(10). These variants belong to the subgroup A2b and are called HMPV A2b180nt-dup and HMPV A2b111nt-dup, respectively (8,10).…”

Section: Short Communicationmentioning

confidence: 99%

Predominant Detection of the Subgroup A2b Human Metapneumovirus Strain with a 111-Nucleotide Duplication in the <i>G</i> gene in Yokohama City, Japan in 2018

Saikusa¹,

Nao

Kawakami³

et al. 2019

Jpn J Infect Dis

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“…A1 and A2a were the least commonly detected subgroups globally and this could probably explain why they were not detected in Kilifi. In contrast to continued circulation of clade A2b (18), in Kilifi, A2b circulated from 2007 to November 2012 and no longer. Occurrence of the clade A2c (41) has increased in Kilifi in recent years, as similarly reported in Bangladesh and Croatia (15,16), suggestive of global spread of HMPV variants.…”

Section: Discussionmentioning

confidence: 93%

Human metapneumovirus prevalence and patterns of genotype persistence identified through surveillance of pediatric pneumonia hospital admissions in coastal Kenya, 2007-2016

Oketch¹,

Kamau²,

Otieno³

et al. 2019

Preprint

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Background Human metapneumovirus (HMPV) is an important respiratory pathogen that causes seasonal epidemics of acute respiratory illness and contributes significantly to childhood pneumonia. Current knowledge and understanding on its patterns of spread, prevalence and persistence in communities is limited. Methods We present findings of a molecular-epidemiological analysis of nasal samples from children < 5 years of age admitted with syndromic pneumonia between 2007 and 2016 to Kilifi County Hospital, coastal Kenya. HMPV infection was detected using real-time RT-PCR and positives sequenced in the fusion (F) and attachment (G) genes followed by phylogenetic analysis. The association between disease severity and HMPV genotype was assessed using Chi-square test for independence. Results Over 10 years, 274/6756 (4.10%) samples screened were HMPV positive. Annual prevalence fluctuated between years ranging 1.2% to 8.7% and lowest in the recent years (2014-2016). HMPV detections were most frequent between October of one year to April of the following year. Genotyping was successful for 205/274 (74.8%) positives revealing A2b (41.0%), A2c (10.7%), B1 (23.4%) and B2 (24.9%). The dominance patterns were: genotype A2b between 2007-11, B1 between 2012-14, and A2c in more recent epidemics. Genotype B2 viruses were present in all the years. These patterns mirrored the global picture. Temporal phylogenetic clustering within the genotypes for both local and global sequence data was seen. Genotypes occurring in each epidemic season were comprised of multiple variants. Pneumonia severity did not vary by genotype (p=0.264). In both the F and G gene, the sequenced regions were found to be predominantly under purifying selection. Conclusion Genotype and strain patterns from this rural African setting temporally map with global strain distribution, suggesting a well-mixed global virus transmission pool of HMPV. Persistence in the local community is characterized by repeated introductions of HMPV variants from the global pool. The factors underlying the declining prevalence of HMPV in this population should be investigated.

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Novel human Metapneumovirus with a 180-Nucleotide Duplication in the G Gene

Abstract: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

Cited by 23 publications

References 16 publications

A novel 111‐nucleotide duplication in the G gene of human metapneumovirus

A novel 111‐nucleotide duplication in the G gene of human metapneumovirus

Predominant Detection of the Subgroup A2b Human Metapneumovirus Strain with a 111-Nucleotide Duplication in the <i>G</i> gene in Yokohama City, Japan in 2018

Human metapneumovirus prevalence and patterns of genotype persistence identified through surveillance of pediatric pneumonia hospital admissions in coastal Kenya, 2007-2016

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