Novel hantavirus identified in European bat species Nyctalus noctula

Abstract

Hantaviruses are emerging RNA viruses that cause human diseases predominantly in Asia, Europe, and the Americas. Besides rodents, insectivores and bats serve as hantavirus reservoirs. We report the detection and genome characterization of a novel bat-borne hantavirus isolated from insectivorous common noctule bat. The newfound virus was tentatively named as Brno virus.

Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

“…Currently Laibin, Longquan and Quezon viruses are the only bat-borne HVs approved by ICTV so far [6, 9, 12]. Among completed genomes, there are the complete coding sequences of the three gene segments of BRNV from the Czech Republic [13]. Here we report the first genomic sequence of XSV and show that XSV and BRNV should be considered new HV species awaiting ICTV consideration.…”

“…We reported the first complete genome of a bat-borne HV, Laibin virus (LAIV), identified from a black-bearded tomb bat in Guangxi Province of China in 2015 [9, 10]. Since then three more complete genomes of bat-borne HVs, Makokou virus (MAKV), Quezon virus (QZNV) and Brno virus (BRNV) have been reported sequentially in 2016, in Central Africa (Gabon), Southeast Asia (Philippines) and Central Europe (Czech Republic), respectively [11–13]. Most recently, a sister lineage of MOUV was detected in dried blood samples from bats in Eastern Africa (Ethiopia) in 2017 [14].…”

What do studies in wild mammals tell us about human emerging viral diseases in Mexico?

“…Until the decade of 2000, Hantaviridae family was restricted to Rodentia, (Padula et al, ; Schmaljohn & Hjelle, ; Torres‐Pérez et al, ); however, since the early 2000s, recent discoveries found some hantavirus species in Indian shrews [order: Soricomorpha] (Klempa et al, ; Zhang, ) and American and European bats (Sabino‐Santos et al, ; Straková et al, ; Těšíková, Bryjová, Bryja, Lavrenchenko, & Goüy de Bellocq, ; Zhang, ). This new information opens the possibility to assess the role of North American shrews and bats as host of hantavirus species.…”

Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam

“…Thus far, only one hantavirus (QZNV) has been found in a flying fox [16], and four hantaviruses (DKGV, LQUV, MAKV, XSV) have been detected hitherto in bats belonging to the Hipposideridae and Rhinolophidae families [9,13,17,18,19] of the suborder Yinpterochiroptera, and five hantaviruses (BRNV, HUPV, LAIV, MGBV, MOYV) have been detected to date in bats belonging to the Emballonuridae, Nycteridae, and Vespertilionidae families [9,10,11,12,13,14,15] of the suborder Yangochiroptera. Thus, irrespective of the classification, bat species in both suborders have been found to host viruses in the newly created genera of Loanvirus and Mobatvirus , suggesting that primordial hantaviruses may have emerged in an early common ancestor of bats or other members of the Laurasiatheria superorder, such as shrews and moles [3,12,13,16,20].…”

“…By contrast, hantaviruses hosted by bats (order Chiropera, suborder Yangochiroptera, and Yinpterochiroptera) have been assigned to the Loanvirus and Mobatvirus genera [2,3]. Members of the genus Loanvirus include Lóngquán virus (LQUV) in the intermediate horseshoe bat ( Rhinolophus affinis ), Formosan lesser horseshoe bat ( Rhinolophus monoceros ) and Chinese rufous horseshoe bat ( Rhinolophus sinicus ) [9] from China, and Brno virus (BRNV) in the common noctule ( Nyctalus noctula ) [10] from the Czech Republic. Other likely members include the Magboi virus (MGBV) in the hairy slit-faced bat ( Nycteris hispida ) [11] from Sierra Leone, Mouyassué virus (MOYV) in the banana pipistrelle ( Neoromicia nanus ) [12,13] from Côte d’Ivoire and in the cape serotine ( Neoromicia capensis ) [14] from Ethiopia, and Huángpí virus (HUPV) in the Japanese house bat ( Pipistrellus abramus ) [9] from China.…”