Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells

Abstract

Keratin expression in stratified epithelia is tightly regulated during squamous cell differentiation. Keratins 5 and 14 are expressed in mitotically active basal layer cells, but their function is not well defined. Reported here is the possible role of K14 in regulation of cell proliferation/differentiation in stratified epithelial cells.

Spatiotemporal regulation of keratin 5 and 17 in the axolotl limb

“…It was recently shown that the basal layer was less proliferative (Satoh et al, 2012a), and KRT5 expression may be associated with the suppression of cell proliferation in the basal layer. In mice, KRT5 is related to keratinocyte proliferation (Alam et al, 2011). The expression of KRT5 in higher vertebrates in a basal layer containing proliferative epidermal stem cells may apply to axolotl AEC.…”

Neurotrophic factor GDNF promotes survival of salivary stem cells

“…The keratin SC markers CK5 and CK14, which are important in maintaining epithelial proliferation (71), are highly expressed in SSCs. Keratin 15 a SC marker in the hair follicle (72), and keratin 17 could compensate for the loss of CK14 in mouse keratinocytes in maintaining cell growth (73).…”

Stem‐Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

“…Cytokeratin 5 (KRT5) is a filament protein that is expressed by epithelial cells and may play a role in maintaining the proliferative capacity of basally located epithelia [27]. We examined the expression of KRT5 in the fallopian tube stem-like cell fraction compared to differentiated FTE by immunostaining tissue sections of normal fallopian tube.…”