Stem‐Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

Paik, Daniel Y.; Janzen, Deanna M.; Schafenacker, Amanda; Velasco, Victor S.; Shung, May S.; Cheng, Donghui; Huang, Jiaoti; Witte, Owen N.; Memarzadeh, Sanaz

doi:10.1002/stem.1207

Cited by 164 publications

(154 citation statements)

References 48 publications

Supporting

Mentioning

147

Contrasting

Unclassified

Order By: Relevance

“…The LGR5-positive population can be activated to divide and differentiate into designated cell types and is responsible for tissue renewal and regeneration. In the Fallopian tubes, these stem-like adult epithelial cells are concentrated at the fimbria (Paik et al 2012, Snegovskikh et al 2014.…”

Section: Pathways Crucial For Ciliogenesis and Ciliary Functionmentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

185

187

View full text Add to dashboard Cite

Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Finally, the review compares different aspects of naturally occurring fertilization and assisted reproductive technology (ART)-achieved fertilization and embryo development, giving insight into potential areas for improvement in this technology.

show abstract

Section: Pathways Crucial For Ciliogenesis and Ciliary Functionmentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

185

187

View full text Add to dashboard Cite

show abstract

“…LRC described by Wang et al (2012) did not express LY6A, CD44, or LGR5. In human, a detailed analysis of the fallopian tube identified a basally located cell (EPCAM C , CD44 C , ITAG6 C , KRT5 C ) that did not express markers of ciliated (TUBB4) or secretory (PAX8) cells (Paik et al 2012). This putative stem cell was able to form spheres in matrigel containing differentiated ciliated and secretory cells as well as CD44…”

Section: Somatic Stem Cells Of the Oviduct/fallopian Tubementioning

confidence: 99%

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Garson¹,

Vanderhyden²

2015

Reproduction

View full text Add to dashboard Cite

The lack of significant progress in the treatment of epithelial ovarian cancer (EOC) underscores the need to gain a better understanding of the processes that lead to chemoresistance and recurrence. The cancer stem cell (CSC) hypothesis offers an attractive explanation of how a subpopulation of cells within a patient's tumour might remain refractory to treatment and subsequently form the basis of recurrent chemoresistant disease. This review examines the literature defining somatic stem cells of the ovary and fallopian tube, two tissues that give rise to EOC. In addition, considerable research has been reviewed, that has identified subpopulations of EOC cells, based on marker expression (CD133, CD44, CD117, CD24, epithelial cell adhesion molecule, LY6A, ALDH1 and side population (SP)), which are enriched for tumour initiating cells (TICs). While many studies identified either CD133 or CD44 as markers useful for enriching for TICs, there is little consensus. This suggests that EOC cells may have a phenotypic plasticity that may preclude the identification of universal markers defining a CSC. The assay that forms the basis of quantifying TICs is the xenograft assay. Considerable controversy surrounds the xenograft assay and it is essential that some of the potential limitations be examined in this review. Highlighting such limitations or weaknesses is required to properly evaluate data and broaden our interpretation of potential mechanisms that might be contributing to the pathogenesis of ovarian cancer.

show abstract

“…Although there is still evidence to support OSE cells as the originating cell type for some ovarian cancers (Auersperg 2013), the fact that both OSE cells and cells within the fallopian tube epithelium express AR (Edmondson et al 2002, Horne et al 2009, Mendez et al 2013 highlights the potential for androgens to modulate disease development and progression. Stem-like epithelial cells from the distal end of the fallopian tube capable of clonal growth and self-renewal have also been identified which may play a role in the initiation of serous tumours, although the impact of androgens on this cell population has not been investigated (Paik et al 2012). The associated increased risk of ovarian cancer in women with endometriosis (Pearce et al 2012) may suggest that AR-positive cells in endometrial tissue might also contribute to development of ovarian cancer as AR protein and mRNA have been reported in both eutopic endometrium and peritoneal lesions in women with peritoneal endometriosis (Carneiro et al 2008).…”

Section: Future Perspectivesmentioning

confidence: 99%

Evidence of androgen action in endometrial and ovarian cancers

Gibson

Simitsidellis

Collins

et al. 2014

Endocrine-Related Cancer

View full text Add to dashboard Cite

Endometrial cancer (EC) and ovarian cancer are common gynaecological malignancies. The impact of androgen action in these cancers is poorly understood; however, there is emerging evidence to suggest that targeting androgen signalling may be of therapeutic benefit. Epidemiological evidence suggests that there is an increased risk of EC associated with exposure to elevated levels of androgens, and genetic variants in genes related to both androgen biosynthesis and action are associated with an increased risk of both EC and ovarian cancer. Androgen receptors (ARs) may be a potential therapeutic target in EC due to reported anti-proliferative activities of androgens. By contrast, androgens may promote growth of some ovarian cancers and anti-androgen therapy has been proposed. Introduction of new therapies targeting ARs expressed in EC or ovarian cancer will require a much greater understanding of the impacts of cell context-specific AR-dependent signalling and how ARs can crosstalk with other steroid receptors during progression of disease. This review considers the evidence that androgens may be important in the aetiology of EC and ovarian cancer with discussion of evidence for androgen action in normal and malignant endometrial and ovarian tissue.

show abstract

Stem‐Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

Cited by 164 publications

References 48 publications

Oviduct: roles in fertilization and early embryo development

Oviduct: roles in fertilization and early embryo development

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Evidence of androgen action in endometrial and ovarian cancers

Contact Info

Product

Resources

About