Novel foot-and-mouth disease virus in Korea, July-August 2014

Park, Jong Hyeon; Tark, Dongseob; Lee, Kwang‐Nyeong; Lee, Seo-Yong; Ko, Mi-Kyeong; Lee, Hyang-Sim; Kim, Su-Mi; Ko, Young-Joon; Seo, Min-Goo; Chun, Ji-Eun; Lee, Myoung-Heon

doi:10.7774/cevr.2016.5.1.83

Cited by 29 publications

(23 citation statements)

References 10 publications

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“…The predominant SEA topotype strain, O/SEA/Mya-98 was mainly restricted to SEA countries until 2010 ( Table 2 ). In 2010–2011 this strain caused devastating outbreaks in FMD free countries, Japan and South Korea [3] , [9] , [10] , [11] , [12] , [13] resulting in high economic losses. O Manisa vaccine was used to control the disease, however full clinical protection was not observed in South Korea.…”

Section: Introductionmentioning

confidence: 99%

Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East

Mahapatra

Upadhyaya

Aviso

et al. 2017

Vaccine

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Foot-and-mouth disease (FMD) is endemic in Southeast Asia (SEA) and East Asia with circulation of multiple serotypes and multiple genotypes within each serotype of the virus. Although countries like Japan and South Korea in the Far East were free of FMD, in 2010 FMD serotype O (O/Mya-98) outbreaks were recorded and since then South Korea has experienced several FMD outbreaks despite regular vaccination. In this study a total of 85 serotype O FMD viruses (FMDV) isolated from 2007 to 2012 from SEA, East Asia and Far East were characterized by virus neutralisation tests using antisera to four existing (O/HKN/6/83, O/IND/R2/75, O/SKR/2010 and O/PanAsia-2) and one putative (O/MYA/2009) vaccine strains, and by full capsid sequencing. Serological studies revealed broad cross-reactivity with the vaccine strains; O/PanAsia-2 exhibited a good match with 95.3%, O/HKN/6/83 with 91.8%, O/IND/R2/75 with 80%, and the putative strain O/MYA/2009 with 89.4% isolates employed in this study. Similarly O/PanAsia-2 and O/IND/R2/75 vaccines showed a good match with all eight viruses belonging to O-Ind-2001d sublineage whereas the vaccines of O/Mya-98 lineage, O/MYA/2009 and O/SKR/2010 exhibited the lowest match indicating their unsuitability to protect infections from O-Ind-2001d viruses. A Bayesian analysis of the capsid sequence data indicated these circulating viruses (n = 85) to be of either SEA or Middle East-South Asian (ME-SA) topotype. The ME-SA topotype viruses were mainly detected in Lao PDR, Vietnam, Myanmar and Thailand reflecting the trade links with the Indian subcontinent, and also within the SEA countries. Implications of these results in the context of FMD control in SEA and East Asian countries are discussed.

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Section: Introductionmentioning

confidence: 99%

Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East

Mahapatra

Upadhyaya

Aviso

et al. 2017

Vaccine

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“…Following a large-scale occurrence of FMD in November 2010, all farm animals susceptible to FMD were vaccinated in Korea [ 11 ]. Occurrence of the disease then appeared to end, but FMD recurred in July, August, and December of 2014, and again from January to March in 2016 [ 12 ]. From 2000 onwards, both type A and type O FMDVs have occurred in Korea.…”

Section: Introductionmentioning

confidence: 99%

Immune responses in pigs and cattle vaccinated with half-volume foot-and-mouth disease vaccine

et al. 2017

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With the current commercial foot-and-mouth disease vaccine, inoculating twice increases the formation of denatured meat due to granuloma or residual adjuvant at the injection site in pigs, resulting in economic loss. Therefore, we investigated protective antibody levels after reducing the amount of adjuvant in the vaccine. Field applicability of the experimental vaccine, made with a new adjuvant ISA 201, was tested by vaccinating farm animals with half-volume doses (1 mL/animal) of commercial vaccine and monitoring their immunogenicity. Among pigs, the group that received a half-volume dose showed similar or higher titers of structural protein antibody and neutralizing antibody than those receiving the standard dose (2 mL). In pigs, the durable effects of antibody titer of the reduced vaccine volume did not diminish up to the time of slaughter. Among cattle, boosting with a second 1 mL vaccine increased virus neutralizing antibody for the protective effects. The boosting effects were more marked in cattle than in pigs. The immune responses differed between species with the effect of the half-volume vaccination being lower in cattle than in pigs. In conclusion, the immune response to the half-volume vaccine was similar to that from the standard volume vaccine in pigs, but not in cattle.

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“…After large-scale type O FMD outbreaks resulted in 153 cases from November 2010 to April 2011, Korea began nationwide administration of vaccinations against the O, A, and Asia1 types of FMDV [ 10 ]. With the continuous occurrence of FMD in neighboring countries such as China, Vietnam, and North Korea, FMD occurred twice in Korea between 2000 and 2002 and five times between 2010 and 2014 [ 8 9 10 11 ]. This was unexpected due to Korea's strong vaccination policies; regardless, the country experienced two more FMD outbreaks after beginning nationwide vaccinations.…”

Section: Introductionmentioning

confidence: 99%

Control of type O foot-and-mouth disease by vaccination in Korea, 2014–2015

et al. 2018

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On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak began in Korea. Although vaccinations were administered, FMD cases increased steadily for five months, and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccination. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea between April 2010 and July 2014. However, the FMD virus isolated in December 2014 had a unique feature; that is, partial deletion of the 5′ non-coding region, a deletion not seen in previous SEA topotype isolates identified in Korea. We conclude that this outbreak included the introduction of a new FMD strain to Korea, and that Korea was now affected by genetically similar FMD virus strains that are related to those from neighboring countries.

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Novel foot-and-mouth disease virus in Korea, July-August 2014

Cited by 29 publications

References 10 publications

Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East

Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East

Immune responses in pigs and cattle vaccinated with half-volume foot-and-mouth disease vaccine

Control of type O foot-and-mouth disease by vaccination in Korea, 2014–2015

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