Novel fluorinated benzimidazole-based scaffolds and their anticancer activity in vitro

Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents

“…(Figure 2). [19] Anticancer agents possessing nitrile functional group could also be counted as apalutamide, bicalutamide, anastrozole, etc. Shao et al designed a series of 4-thiazol-2-anilinopyrimidine derivatives with cyano groups attached to the C5-position of the pyrimidine and investigated their effects on CDK9 potency and selectivity.…”

Crystal structures and Hirshfeld surface analysis of a series of 4-O-arylperfluoropyridines

“…As a result of the presence of five fluorine atoms, in addition to the nitrogen atom of the pyridine ring, these systems are highly electrophilic and undergo substitution reactions readily in a predictable pattern (Baker & Muir, 2010;Chambers et al, 1988). This chemistry has already been used in the design of several drugs (Bhambra et al, 2016) and in peptide modification (Gimenez et al, 2017). In an effort to further understand the intermolecular interactions in the solid state of these fluorinated compounds, five new crystal structures of pentafluoropyridine derivatives are herein reported as well as their syntheses.…”

2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide

“…Benzimidazole and its derivatives have associated with diverse biological activities such as anti-microbial [7][8][9], anti-inflammatory and analgesic [10], anti-tubercular [11], anti-oxidant [12], anti-fungal [13], anti-convulsant/anti-diabetic [14], and anti-viral [15]. Substituted benzimidazole derivatives have found commercial applications in diverse human therapeutics, especially for treating various types of cancers [16][17][18][19][20]. Carboxamide compounds have diversified applications in medicinal chemistry as an important pharmacophore found in many marketed drug molecules [21].…”

“…Thus, in this paper we describe the efficient synthesis and characterization (by IR, 1 H-NMR, 13 C-NMR, and LC-MS spectral data) of new benzimidazole coupled carboxamide. derivatives have found commercial applications in diverse human therapeutics, especially for treating various types of cancers [16][17][18][19][20]. Carboxamide compounds have diversified applications in medicinal chemistry as an important pharmacophore found in many marketed drug molecules [21].…”