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2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide was synthesized by the ‘one-pot’ reductive cyclization of N-(4-methoxyphenyl)-3-nitro-4-(propylamino)benzamide with 3,4-dimethoxybenzaldehyde, using sodium dithionite as a reductive cyclizing agent using DMSO as a solvent. The structure of newly synthesized compound was elucidated based on IR, 1H-NMR, 13C-NMR, and LC-MS data.

A new ABTS-radical scavenging and antiproliferative agents of pyrrolo[1,2-a]quinoline derivatives have been synthesized. An efficient method for the synthesis of fourteen novel diversified pyrrolo[1,2-a]quinoline derivatives has been described using 4-(1,3-dioxolan-2-yl)quinoline and different phenacyl bromides in acetone and followed by reacting with different acetylenes in DMF/K 2 CO 3 . The structure of the newly synthesized compounds was determined by IR, 1 H NMR, 13 C NMR, mass spectrometry and elemental analysis. The in vitro antioxidant activity revealed that, among all the tested compounds 5n has exhibited maximum scavenging activity with ABTS. The compound 5b has showed good antiproliferative activity as good inhibitor of EGFR tyrosine kinase.

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