Novel fluoride rechargeable dental composites containing MgAl and CaAl layered double hydroxide (LDH)

Hoxha, Agron; Gillam, DG; Agha, Amani; Karpukhina, Natalia; Bushby, A. J.; Patel, Mukesh R.

doi:10.1016/j.dental.2020.04.011

Cited by 15 publications

(21 citation statements)

References 59 publications

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“…To maintain a sustained low concentration of fluoride in the oral environment, a material incorporating layered double hydroxides (LDHs) was investigated, which was also rendered fluoride-rechargeable [ 57 , 58 ]. Su et al developed a novel fluoride-charged LiAl-F LDH and added it to dental composites.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…A study by Hoxha et al incorporated MgAl and CaAl LDH into experimental dental composites, and investigated the ability of fluoride release and its effect on the mechanical properties of resin composites. The results showed that CaAl LDH and MgAl LDH composites repeatedly absorbed/released fluoride and maintained the desired physical-mechanical properties [ 58 ].…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…As mentioned above, many related research has been carried out to achieve the controlled release of antimicrobial agents under the premise of maintaining the mechanical properties [ 49 , 50 , 51 ]. Research focuses have included the development of drug-carrying systems [ 52 , 54 ], smart release systems [ 60 , 62 ] and recharging materials [ 57 , 58 ]. However, the antimicrobial agents contained in the drug-carrying systems and the smart release systems are not endless.…”

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

“…Once the antimicrobial agents have been completely released, the composite will lose its antimicrobial effect [ 23 ]. For rechargeable materials, the charging process needs to be repeated, increasing the treatment procedures [ 57 , 58 ]. The development of a controlled release system that would not become exhausted is a major challenge we face.…”

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

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Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

Section: Challenges Faced By Antimicrobial Dental Restorationsmentioning

confidence: 99%

See 2 more Smart Citations

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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“…Fluoride is widely used in dental products because primarily via topical mechanisms, it has a cariostatic effect inhibiting the demineralization at the crystal surfaces, enhancing the remineralization, interfering with plaque formation and inhibiting bacterial metabolism [5,10,21,[28][29][30][31][32]. The presence of fluoride ions restricts the formation of acidic, more soluble calcium phosphates as dicalcium phosphate dihydrate or octacalcium phosphate, and facilitates the creation of more acid-resistant fluorapatite or fluorhydroxyapatite (partial substitution of fluoride by hydroxyl groups).…”

Section: Introductionmentioning

confidence: 99%

The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

2022

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This study aims to develop an innovative dental product to remineralize dental enamel by a proper combination of ion-exchange resins as controlled release of mineral ions that form dental enamel, in the presence of amelogenin to guide the appropriate crystal growth. The novel product proposed consists of a combination of ion-exchange resins (weak acid and weak base) individually loaded with the remineralizing ions: Ca2+, PO43− and F−, also including Zn2+ in a minor amount as antibacterial, together with the protein amelogenin. Such cocktail provides onsite controlled release of the ions necessary for enamel remineralization due to the weak character of the resins and at the same time, a guiding tool for related crystal growth by the indicated protein. Amelogenin protein is involved in the structural development of natural enamel and takes a key role in controlling the crystal growth morphology and alignment at the enamel surface. Bovine teeth were treated by applying the resins and protein together with artificial saliva. Treated teeth were evaluated with nanoindentation, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The innovative material induces the dental remineralization creating a fluorapatite layer with a hardness equivalent to sound enamel, with the appropriate alignment of corresponding nanocrystals, being the fluorapatite more acid resistant than the original mineral. Our results suggest that the new product shows potential for promoting long-term remineralization leading to the inhibition of caries and protection of dental structures.

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Restoration of Carious Hard Dental Tissues

Kotsanos

Wong

2022

Pediatric Dentistry

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Novel fluoride rechargeable dental composites containing MgAl and CaAl layered double hydroxide (LDH)

Cited by 15 publications

References 59 publications

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

Restoration of Carious Hard Dental Tissues

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