Novel flavonoid glycosides from the bulbs of Urginea indica Kunth

Abstract

Three novel flavonoid glycosides, 5,6-dimethyoxy-3',4''-dioxymethylene-7-O-(6''-beta-D-glucopyranosyl-beta-D-glucopyranosyl) flavanone (1), 5,4'-dihydroxy-3-O-alpha-L-rhamnopyranosyl-6-C-glucopyranosyl-7-O-(6''-para-coumaroyl-beta-D-glucopyranosyl) flavone (2) and 5,4'-dihydroxy-3-O-(2'''''-beta-glucopyranosyl-alpha-L-rhamnopyranosyl)-6-C-glucopyranosyl-7-O-(6''-para-coumaroyl-beta-D-glucopyranosyl) flavone (3) were isolated from the 1-butanol soluble fraction of the bulbs of the plant Urginea indica (Indian squill). The structures of the compounds were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlation NMR experiments (COSY, NOESY, HSQC and HMBC) and mass spectra.

Anin silicoperception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

“…Approved for hospitalized cases Nitazoxanide 28 Orally active broad-spectrum antiparasitic Prodrug transformed rapidly to active metabolites, such as, tizoxanide and tizoxanide Known to potentiate interferon-alfa and interferon-beta assembly Previously revealed an in vitro activity against MERS-CoV and other coronaviruses Recommended in combination with azithromycin Thalidomide Thalidomide has been repurposed with different pharmacological effects It was reported as an anti-inammatory drug as it prevents the synthesis of TNF-a, 29 treating H1N1-infected mice by reducing pro-inammatory cytokines 30 Present studies are based on its immunomodulatory properties to treat COVID-19 (NCT04273529, NCT04273581), phase 2 carbon at d C 105.12, which conrmed the presence of glucose moiety. 44 The HMBC spectrum showed a signicant correlation between the anomeric proton (H-1 00 ) at d H 4.7 of glucose moiety and the carbon (C-7) at d C 162.52. 43,45 The elucidation of the absolute conguration at C-2 was based on the values of coupling constants with methylenic protons H-3 a,b (Jax-ax ¼ 12.6 and Jax-eq ¼ 3 Hz).…”

Drimia indica: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses

“…The plant D. indica contains a variety of bioactive constituents, including alkaloids, sterols, flavonoids, anthraquinones, and coumarins [53,54,55]. Many other constituents, such as tannins, quinones, resins, saponins, phenolics, protein, and carbohydrates such as sucrose, maltose, fructose, and galactose, have also been reported in different parts of the plant [11,24,43].…”

C-glycosyl flavone from Urginea indica inhibits proliferation & angiogenesis & induces apoptosis via cyclin-dependent kinase 6 in human breast, hepatic & colon cancer cell lines

“…Deepak and Salimath 12 reported a novel glycoprotein with anti-angiogenic and pro-apoptotic activity. Sultana et al 13 reported O-glycosyl flavone and flavonone in the bulb. However, the search for novel compounds that could be beneficial for the treatment of cancer is continued.…”